Ionic mechanism underlying optimal stimuli for neuronal excitation: role of Na+ channel inactivation.

Ionic mechanism underlying optimal stimuli for neuronal excitation: role of Na+ channel inactivation.

The ionic mechanism underlying optimal stimulus shapes that induce a neuron to fire an action potential, or spike, is relevant to understanding optimal information transmission and therapeutic stimulation in the nervous system. Here we analyze for the first time the ionic basis for stimulus optimali...

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Bibliographic Details
Main Authors: John R Clay, Daniel B Forger, David Paydarfar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3458826?pdf=render

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