Cortactin tyrosine phosphorylation promotes its deacetylation and inhibits cell spreading.

Cortactin tyrosine phosphorylation promotes its deacetylation and inhibits cell spreading.

BACKGROUND: Cortactin is a classical Src kinase substrate that participates in actin cytoskeletal dynamics by activating the Arp2/3 complex and interacting with other regulatory proteins, including FAK. Cortactin has various domains that may contribute to the assembly of different protein platforms...

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Bibliographic Details
Main Authors: Eugenia Meiler, Elvira Nieto-Pelegrín, Narcisa Martinez-Quiles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3316595?pdf=render

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