Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on several brain biological processes; they are involved in a variety of neuronal diseases including Parkinson’s disease, Alz...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661823000671 |
| _version_ | 1797448151906385920 |
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| author | Federica Bono Chiara Fiorentini Veronica Mutti Zaira Tomasoni Giulia Sbrini Hanna Trebesova Mario Marchi Massimo Grilli Cristina Missale |
| author_facet | Federica Bono Chiara Fiorentini Veronica Mutti Zaira Tomasoni Giulia Sbrini Hanna Trebesova Mario Marchi Massimo Grilli Cristina Missale |
| author_sort | Federica Bono |
| collection | DOAJ |
| description | Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on several brain biological processes; they are involved in a variety of neuronal diseases including Parkinson’s disease, Alzheimer’s disease, epilepsy, and nicotine addiction. The influence of nAChRs on brain function depends on the activity of other neurotransmitter receptors that co-exist with nAChRs on neurons. In fact, the crosstalk between receptors is an important mechanism of neurotransmission modulation and plasticity. This may be due to converging intracellular pathways but also occurs at the membrane level, because of direct physical interactions between receptors. In this line, this review is dedicated to summarizing how nAChRs and other ionotropic and metabotropic receptors interact and the relevance of nAChRs cross-talks in modulating various neuronal processes ranging from the classical modulation of neurotransmitter release to neuron plasticity and neuroprotection. |
| first_indexed | 2024-03-09T14:06:20Z |
| format | Article |
| id | doaj.art-dc9ca083b90e46e6b1c428ebf02756a5 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-09T14:06:20Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-dc9ca083b90e46e6b1c428ebf02756a52023-11-30T05:05:54ZengElsevierPharmacological Research1096-11862023-04-01190106711Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptorsFederica Bono0Chiara Fiorentini1Veronica Mutti2Zaira Tomasoni3Giulia Sbrini4Hanna Trebesova5Mario Marchi6Massimo Grilli7Cristina Missale8Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Pharmacy, University of Genova, 16148 Genoa, ItalyDepartment of Pharmacy, University of Genova, 16148 Genoa, ItalyDepartment of Pharmacy, University of Genova, 16148 Genoa, Italy; Correspondence to: University of Genova, 16148 Genoa, Italy.Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyNeuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on several brain biological processes; they are involved in a variety of neuronal diseases including Parkinson’s disease, Alzheimer’s disease, epilepsy, and nicotine addiction. The influence of nAChRs on brain function depends on the activity of other neurotransmitter receptors that co-exist with nAChRs on neurons. In fact, the crosstalk between receptors is an important mechanism of neurotransmission modulation and plasticity. This may be due to converging intracellular pathways but also occurs at the membrane level, because of direct physical interactions between receptors. In this line, this review is dedicated to summarizing how nAChRs and other ionotropic and metabotropic receptors interact and the relevance of nAChRs cross-talks in modulating various neuronal processes ranging from the classical modulation of neurotransmitter release to neuron plasticity and neuroprotection.http://www.sciencedirect.com/science/article/pii/S1043661823000671Neuronal nicotinic receptorsHeteromersCrosstalkDopamine releaseReceptor-receptor interaction |
| spellingShingle | Federica Bono Chiara Fiorentini Veronica Mutti Zaira Tomasoni Giulia Sbrini Hanna Trebesova Mario Marchi Massimo Grilli Cristina Missale Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors Pharmacological Research Neuronal nicotinic receptors Heteromers Crosstalk Dopamine release Receptor-receptor interaction |
| title | Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors |
| title_full | Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors |
| title_fullStr | Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors |
| title_full_unstemmed | Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors |
| title_short | Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors |
| title_sort | central nervous system interaction and crosstalk between nachrs and other ionotropic and metabotropic neurotransmitter receptors |
| topic | Neuronal nicotinic receptors Heteromers Crosstalk Dopamine release Receptor-receptor interaction |
| url | http://www.sciencedirect.com/science/article/pii/S1043661823000671 |
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