A Novel Murine Multi-Hit Model of Perinatal Acute Diffuse White Matter Injury Recapitulates Major Features of Human Disease

A Novel Murine Multi-Hit Model of Perinatal Acute Diffuse White Matter Injury Recapitulates Major Features of Human Disease

The selection of an appropriate animal model is key to the production of results with optimal relevance to human disease. Particularly in the case of perinatal brain injury, a dearth of affected human neonatal tissue available for research purposes increases the reliance on animal models for insight...

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Bibliographic Details
Main Authors: Patricia Renz, Andreina Schoeberlein, Valérie Haesler, Theoni Maragkou, Daniel Surbek, Amanda Brosius Lutz
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
perinatal brain injury
diffuse injury
white matter injury
mouse model
gliosis
myelination failure
Online Access:https://www.mdpi.com/2227-9059/10/11/2810

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