Synthesis and antimicrobial activity of α-aminophosphonates containing chitosan moiety
A novel series of α-aminophosphonates containing chitosan moiety was obtained in high yields from reactions of chitosan with aromatic aldehydes and triphenylphosphite in the presence of lithium perchlorate as a catalyst. The structures of the synthesized compounds were confirmed by IR and 1H NMR spe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-05-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535214000069 |
| _version_ | 1818673319988166656 |
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| author | El-Refaie S. Kenawy Mohamed M. Azaam Khalil M. Saad-Allah |
| author_facet | El-Refaie S. Kenawy Mohamed M. Azaam Khalil M. Saad-Allah |
| author_sort | El-Refaie S. Kenawy |
| collection | DOAJ |
| description | A novel series of α-aminophosphonates containing chitosan moiety was obtained in high yields from reactions of chitosan with aromatic aldehydes and triphenylphosphite in the presence of lithium perchlorate as a catalyst. The structures of the synthesized compounds were confirmed by IR and 1H NMR spectral data. Compounds (1–4) showed high antimicrobial activities against Escherichia coli (NCIM2065), Serratia marcescens, Enterobacter cloacae, Shigella dysenteriae, Salmonella enterica and Proteus vulgaris as Gram-negative bacteria, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram-positive bacteria and Candida albicans as a fungus, at low concentrations (2.5–10 mg/mL). |
| first_indexed | 2024-12-17T07:53:55Z |
| format | Article |
| id | doaj.art-dca0d0c761e0446b9126f2849a819e42 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-17T07:53:55Z |
| publishDate | 2015-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-dca0d0c761e0446b9126f2849a819e422022-12-21T21:57:46ZengElsevierArabian Journal of Chemistry1878-53522015-05-018342743210.1016/j.arabjc.2013.12.029Synthesis and antimicrobial activity of α-aminophosphonates containing chitosan moietyEl-Refaie S. Kenawy0Mohamed M. Azaam1Khalil M. Saad-Allah2Chemistry Department, Faculty of Science, Tanta University, Tanta, EgyptChemistry Department, Faculty of Science, Tanta University, Tanta, EgyptBotany Department, Faculty of Science, Tanta University, Tanta, EgyptA novel series of α-aminophosphonates containing chitosan moiety was obtained in high yields from reactions of chitosan with aromatic aldehydes and triphenylphosphite in the presence of lithium perchlorate as a catalyst. The structures of the synthesized compounds were confirmed by IR and 1H NMR spectral data. Compounds (1–4) showed high antimicrobial activities against Escherichia coli (NCIM2065), Serratia marcescens, Enterobacter cloacae, Shigella dysenteriae, Salmonella enterica and Proteus vulgaris as Gram-negative bacteria, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram-positive bacteria and Candida albicans as a fungus, at low concentrations (2.5–10 mg/mL).http://www.sciencedirect.com/science/article/pii/S1878535214000069α-AminophosphonateChitosanAntimicrobial polymersBiomedical polymers |
| spellingShingle | El-Refaie S. Kenawy Mohamed M. Azaam Khalil M. Saad-Allah Synthesis and antimicrobial activity of α-aminophosphonates containing chitosan moiety Arabian Journal of Chemistry α-Aminophosphonate Chitosan Antimicrobial polymers Biomedical polymers |
| title | Synthesis and antimicrobial activity of α-aminophosphonates containing chitosan moiety |
| title_full | Synthesis and antimicrobial activity of α-aminophosphonates containing chitosan moiety |
| title_fullStr | Synthesis and antimicrobial activity of α-aminophosphonates containing chitosan moiety |
| title_full_unstemmed | Synthesis and antimicrobial activity of α-aminophosphonates containing chitosan moiety |
| title_short | Synthesis and antimicrobial activity of α-aminophosphonates containing chitosan moiety |
| title_sort | synthesis and antimicrobial activity of α aminophosphonates containing chitosan moiety |
| topic | α-Aminophosphonate Chitosan Antimicrobial polymers Biomedical polymers |
| url | http://www.sciencedirect.com/science/article/pii/S1878535214000069 |
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