Association of haematological biomarkers with severity of COVID-19 pneumonia
Background: Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China in December 2019. It is caused by SARS-CoV-2, a beta coronavirus. In this study, we assessed the association of biomarkers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte mono...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=9;spage=3325;epage=3329;aulast=Kaeley |
| _version_ | 1819011687535083520 |
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| author | Nidhi Kaeley Prakash Mahala Rohit Walia V Subramanyam Suman Choudhary Takshak Shankar |
| author_facet | Nidhi Kaeley Prakash Mahala Rohit Walia V Subramanyam Suman Choudhary Takshak Shankar |
| author_sort | Nidhi Kaeley |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China in December 2019. It is caused by SARS-CoV-2, a beta coronavirus. In this study, we assessed the association of biomarkers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte monocyte ratio (LMR) with the severity of COVID-19 in patients. Methods: This retrospective observational study was carried out at a tertiary care hospital of the sub-Himalayan region of Uttarakhand over a period of six months from May to October 2020. A total of 350 patients with confirmed RT-PCR COVID-19 infection were included in the study. Detailed clinical, demographic and biochemical data of each patient was obtained from the hospital record section after permission from the Institute Ethical Committee. NLR, PLR and LMR ratios were calculated and compared with the outcomes in each patient. The patients were subdivided into two sub-groups: those with saturation less than 94% and those with saturation more than 94%. The patients were categorised as mild (with SpO2 of > 94%) and moderate-severe (with SpO2 of ≤94%) based on oxygen saturation. Results: A total of 350 patients with Covid-19 pneumonia were enrolled in the study. The mean age of the patients with oxygen saturation of ≤94% was 54.91 ± 13.29 years, which was comparable to the other group. Absolute neutrophil count (ANC) and NLR were significantly higher in patients with a saturation of < 94%. However, LMR and PLR were significantly lower in the group with saturation of <94%. Thus, a significant association was found between haematological inflammatory ratios and the severity of COVID-19 infection. Conclusion: NLR, LMR and PLR ratios can be utilised as point of care markers to assess severity in patients with COVID-19 pneumonia. |
| first_indexed | 2024-12-21T01:32:07Z |
| format | Article |
| id | doaj.art-dca0f4599fa04cab96ba263e050d7e03 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-21T01:32:07Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-dca0f4599fa04cab96ba263e050d7e032022-12-21T19:20:20ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632021-01-011093325332910.4103/jfmpc.jfmpc_617_21Association of haematological biomarkers with severity of COVID-19 pneumoniaNidhi KaeleyPrakash MahalaRohit WaliaV SubramanyamSuman ChoudharyTakshak ShankarBackground: Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China in December 2019. It is caused by SARS-CoV-2, a beta coronavirus. In this study, we assessed the association of biomarkers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte monocyte ratio (LMR) with the severity of COVID-19 in patients. Methods: This retrospective observational study was carried out at a tertiary care hospital of the sub-Himalayan region of Uttarakhand over a period of six months from May to October 2020. A total of 350 patients with confirmed RT-PCR COVID-19 infection were included in the study. Detailed clinical, demographic and biochemical data of each patient was obtained from the hospital record section after permission from the Institute Ethical Committee. NLR, PLR and LMR ratios were calculated and compared with the outcomes in each patient. The patients were subdivided into two sub-groups: those with saturation less than 94% and those with saturation more than 94%. The patients were categorised as mild (with SpO2 of > 94%) and moderate-severe (with SpO2 of ≤94%) based on oxygen saturation. Results: A total of 350 patients with Covid-19 pneumonia were enrolled in the study. The mean age of the patients with oxygen saturation of ≤94% was 54.91 ± 13.29 years, which was comparable to the other group. Absolute neutrophil count (ANC) and NLR were significantly higher in patients with a saturation of < 94%. However, LMR and PLR were significantly lower in the group with saturation of <94%. Thus, a significant association was found between haematological inflammatory ratios and the severity of COVID-19 infection. Conclusion: NLR, LMR and PLR ratios can be utilised as point of care markers to assess severity in patients with COVID-19 pneumonia.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=9;spage=3325;epage=3329;aulast=Kaeleyassociation of nlrlmrplrseverity of covid-19 |
| spellingShingle | Nidhi Kaeley Prakash Mahala Rohit Walia V Subramanyam Suman Choudhary Takshak Shankar Association of haematological biomarkers with severity of COVID-19 pneumonia Journal of Family Medicine and Primary Care association of nlr lmr plr severity of covid-19 |
| title | Association of haematological biomarkers with severity of COVID-19 pneumonia |
| title_full | Association of haematological biomarkers with severity of COVID-19 pneumonia |
| title_fullStr | Association of haematological biomarkers with severity of COVID-19 pneumonia |
| title_full_unstemmed | Association of haematological biomarkers with severity of COVID-19 pneumonia |
| title_short | Association of haematological biomarkers with severity of COVID-19 pneumonia |
| title_sort | association of haematological biomarkers with severity of covid 19 pneumonia |
| topic | association of nlr lmr plr severity of covid-19 |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=9;spage=3325;epage=3329;aulast=Kaeley |
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