Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study
Purpose: The aim of the present study is to evaluate the influence and efficacy of autologous platelets on bone regeneration in a rabbit defects model. Materials and Methods: A total of 12 critical size tibial defects were produced in six New Zealand rabbits: A total of six defects were filled with...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/1/395 |
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| author | Antonio Scarano Francesco Inchingolo Biagio Rapone Alberta Greco Lucchina Erda Qorri Felice Lorusso |
| author_facet | Antonio Scarano Francesco Inchingolo Biagio Rapone Alberta Greco Lucchina Erda Qorri Felice Lorusso |
| author_sort | Antonio Scarano |
| collection | DOAJ |
| description | Purpose: The aim of the present study is to evaluate the influence and efficacy of autologous platelets on bone regeneration in a rabbit defects model. Materials and Methods: A total of 12 critical size tibial defects were produced in six New Zealand rabbits: A total of six defects were filled with autologous platelet gel (APG) and six defects were maintained as untreated controls. No membranes were used to cover the bone osteotomies. The histology and histomorphometry were performed at four weeks on retrieved samples of both groups. Results: No complications were reported in any of the animals nor for the defects produced. A significantly higher lamellar and woven bone percentage was reported for the APG group with a lower level of marrow spaces (<i>p</i> < 0.05). Evidence of newly formed bone was found in the superficial portion of the bone defect of APG samples where no aspects of bone resorption were observed. Conclusions: The evidence of the present research revealed that APG increases new bone formation restricted to the cortical portion and induces more rapid healing in rabbit bone defects than in untreated defects. |
| first_indexed | 2024-03-10T13:31:26Z |
| format | Article |
| id | doaj.art-dca1a32de00e484c8c465590241625e7 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T13:31:26Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj.art-dca1a32de00e484c8c465590241625e72023-11-21T08:00:03ZengMDPI AGApplied Sciences2076-34172021-01-0111139510.3390/app11010395Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit StudyAntonio Scarano0Francesco Inchingolo1Biagio Rapone2Alberta Greco Lucchina3Erda Qorri4Felice Lorusso5Department of Innovative Technologies in Medicine & Dentistry, University of Chieti-Pescara, Via Dei Vestini, 31, 66100 Chieti, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari, 70121 Bari, ItalyOral Surgery Unit, University of Eastern Piedmont, Via Lanino 1, 28100 Novara, ItalyDean Faculty of Medical Sciences, Albanian University, Bulevardi Zogu I, 1001 Tirana, AlbaniaDepartment of Innovative Technologies in Medicine & Dentistry, University of Chieti-Pescara, Via Dei Vestini, 31, 66100 Chieti, ItalyPurpose: The aim of the present study is to evaluate the influence and efficacy of autologous platelets on bone regeneration in a rabbit defects model. Materials and Methods: A total of 12 critical size tibial defects were produced in six New Zealand rabbits: A total of six defects were filled with autologous platelet gel (APG) and six defects were maintained as untreated controls. No membranes were used to cover the bone osteotomies. The histology and histomorphometry were performed at four weeks on retrieved samples of both groups. Results: No complications were reported in any of the animals nor for the defects produced. A significantly higher lamellar and woven bone percentage was reported for the APG group with a lower level of marrow spaces (<i>p</i> < 0.05). Evidence of newly formed bone was found in the superficial portion of the bone defect of APG samples where no aspects of bone resorption were observed. Conclusions: The evidence of the present research revealed that APG increases new bone formation restricted to the cortical portion and induces more rapid healing in rabbit bone defects than in untreated defects.https://www.mdpi.com/2076-3417/11/1/395autologous platelet gelnew bone formationbone repairplatelet derivates |
| spellingShingle | Antonio Scarano Francesco Inchingolo Biagio Rapone Alberta Greco Lucchina Erda Qorri Felice Lorusso Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study Applied Sciences autologous platelet gel new bone formation bone repair platelet derivates |
| title | Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study |
| title_full | Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study |
| title_fullStr | Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study |
| title_full_unstemmed | Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study |
| title_short | Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study |
| title_sort | role of autologous platelet gel apg in bone healing a rabbit study |
| topic | autologous platelet gel new bone formation bone repair platelet derivates |
| url | https://www.mdpi.com/2076-3417/11/1/395 |
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