Peptidoglycan sensing by octopaminergic neurons modulates Drosophila oviposition
As infectious diseases pose a threat to host integrity, eukaryotes have evolved mechanisms to eliminate pathogens. In addition to develop strategies reducing infection, animals can engage in behaviors that lower the impact of the infection. The molecular mechanisms by which microbes impact host beha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/21937 |
| _version_ | 1811200695853907968 |
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| author | C Leopold Kurz Bernard Charroux Delphine Chaduli Annelise Viallat-Lieutaud Julien Royet |
| author_facet | C Leopold Kurz Bernard Charroux Delphine Chaduli Annelise Viallat-Lieutaud Julien Royet |
| author_sort | C Leopold Kurz |
| collection | DOAJ |
| description | As infectious diseases pose a threat to host integrity, eukaryotes have evolved mechanisms to eliminate pathogens. In addition to develop strategies reducing infection, animals can engage in behaviors that lower the impact of the infection. The molecular mechanisms by which microbes impact host behavior are not well understood. We demonstrate that bacterial infection of Drosophila females reduces oviposition and that peptidoglycan, the component that activates Drosophila antibacterial response, is also the elicitor of this behavioral change. We show that peptidoglycan regulates egg-laying rate by activating NF-κB signaling pathway in octopaminergic neurons and that, a dedicated peptidoglycan degrading enzyme acts in these neurons to buffer this behavioral response. This study shows that a unique ligand and signaling cascade are used in immune cells to mount an immune response and in neurons to control fly behavior following infection. This may represent a case of behavioral immunity. |
| first_indexed | 2024-04-12T02:08:23Z |
| format | Article |
| id | doaj.art-dca38c262ce54faeb6b7aaa1abeb97b5 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:08:23Z |
| publishDate | 2017-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-dca38c262ce54faeb6b7aaa1abeb97b52022-12-22T03:52:29ZengeLife Sciences Publications LtdeLife2050-084X2017-03-01610.7554/eLife.21937Peptidoglycan sensing by octopaminergic neurons modulates Drosophila ovipositionC Leopold Kurz0Bernard Charroux1https://orcid.org/0000-0002-3359-4066Delphine Chaduli2Annelise Viallat-Lieutaud3Julien Royet4https://orcid.org/0000-0002-5671-4833Aix-Marseille Université, Centre National de la Recherche Scientifique, UMR 7288, Institut de Biologie du Développement de Marseille, Marseille Cedex, FranceAix-Marseille Université, Centre National de la Recherche Scientifique, UMR 7288, Institut de Biologie du Développement de Marseille, Marseille Cedex, FranceAix-Marseille Université, Centre National de la Recherche Scientifique, UMR 7288, Institut de Biologie du Développement de Marseille, Marseille Cedex, FranceAix-Marseille Université, Centre National de la Recherche Scientifique, UMR 7288, Institut de Biologie du Développement de Marseille, Marseille Cedex, FranceAix-Marseille Université, Centre National de la Recherche Scientifique, UMR 7288, Institut de Biologie du Développement de Marseille, Marseille Cedex, FranceAs infectious diseases pose a threat to host integrity, eukaryotes have evolved mechanisms to eliminate pathogens. In addition to develop strategies reducing infection, animals can engage in behaviors that lower the impact of the infection. The molecular mechanisms by which microbes impact host behavior are not well understood. We demonstrate that bacterial infection of Drosophila females reduces oviposition and that peptidoglycan, the component that activates Drosophila antibacterial response, is also the elicitor of this behavioral change. We show that peptidoglycan regulates egg-laying rate by activating NF-κB signaling pathway in octopaminergic neurons and that, a dedicated peptidoglycan degrading enzyme acts in these neurons to buffer this behavioral response. This study shows that a unique ligand and signaling cascade are used in immune cells to mount an immune response and in neurons to control fly behavior following infection. This may represent a case of behavioral immunity.https://elifesciences.org/articles/21937drosophilainnate immunityoctopaminergic neuronsNF-kBbehaviourIMD |
| spellingShingle | C Leopold Kurz Bernard Charroux Delphine Chaduli Annelise Viallat-Lieutaud Julien Royet Peptidoglycan sensing by octopaminergic neurons modulates Drosophila oviposition eLife drosophila innate immunity octopaminergic neurons NF-kB behaviour IMD |
| title | Peptidoglycan sensing by octopaminergic neurons modulates Drosophila oviposition |
| title_full | Peptidoglycan sensing by octopaminergic neurons modulates Drosophila oviposition |
| title_fullStr | Peptidoglycan sensing by octopaminergic neurons modulates Drosophila oviposition |
| title_full_unstemmed | Peptidoglycan sensing by octopaminergic neurons modulates Drosophila oviposition |
| title_short | Peptidoglycan sensing by octopaminergic neurons modulates Drosophila oviposition |
| title_sort | peptidoglycan sensing by octopaminergic neurons modulates drosophila oviposition |
| topic | drosophila innate immunity octopaminergic neurons NF-kB behaviour IMD |
| url | https://elifesciences.org/articles/21937 |
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