Amoxicillin Haptenation of α-Enolase is Modulated by Active Site Occupancy and Acetylation

Amoxicillin Haptenation of α-Enolase is Modulated by Active Site Occupancy and Acetylation

Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the modification of proteins by covalent binding of the drug (haptenation). Hence, i...

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Bibliographic Details
Main Authors: Juan M. González-Morena, Francisco J. Sánchez-Gómez, Yolanda Vida, Ezequiel Pérez-Inestrosa, María Salas, María I. Montañez, Alessandra Altomare, Giancarlo Aldini, María A. Pajares, Dolores Pérez-Sala
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
beta-lactam antibiotics
protein modification by drugs
mass spectrometry
posttranslational modification
acetylation
allergic responses to drugs
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.807742/full

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