Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS)
Fetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation and prefrontal cortex lesions; however, whether air-purifier usage, which can reduce indoor PM levels, is related to infant developmental delay remains unknown. We therefore examined...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/6/1924 |
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| author | Kenta Matsumura Kei Hamazaki Akiko Tsuchida Hidekuni Inadera The Japan Environment and Children’s Study (JECS) Group |
| author_facet | Kenta Matsumura Kei Hamazaki Akiko Tsuchida Hidekuni Inadera The Japan Environment and Children’s Study (JECS) Group |
| author_sort | Kenta Matsumura |
| collection | DOAJ |
| description | Fetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation and prefrontal cortex lesions; however, whether air-purifier usage, which can reduce indoor PM levels, is related to infant developmental delay remains unknown. We therefore examined the prospective relationship between air-purifier usage during pregnancy and infant developmental delay by analyzing 82,441 mother–infant pairs using a simple yes/no questionnaire. Developmental delays at 6 and 12 months were assessed in five areas using the Ages and Stages Questionnaire, Third Edition. A generalized linear mixed model analysis was used to derive adjusted odds ratios (AORs) and 95% confidence intervals (95% CIs) while controlling for 20 covariates. The analysis revealed that air-purifier usage was associated with developmental delays in fine motor (AOR: 0.91, 95% CI: 0.83–0.99) and problem solving (AOR: 0.83, 95% CI: 0.77–0.90) at 6 months and in communication (AOR: 0.86, 95% CI: 0.79–0.93), fine motor (AOR: 0.87, 95% CI: 0.82–0.92), problem solving (AOR: 0.83, 95% CI: 0.77–0.88), and personal–social (AOR: 0.79, 95% CI: 0.72–0.86) at 12 months. In conclusion, a negative association exists between air-purifier usage during pregnancy and infant neurodevelopmental delay that strengthens with time. Our results outline the potential role of air purifiers in inhibiting infant neurodevelopmental delay. |
| first_indexed | 2024-03-10T19:01:42Z |
| format | Article |
| id | doaj.art-dcafb203ac3e4f599cc06598b47661b6 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:01:42Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-dcafb203ac3e4f599cc06598b47661b62023-11-20T04:23:18ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0196192410.3390/jcm9061924Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS)Kenta Matsumura0Kei Hamazaki1Akiko Tsuchida2Hidekuni Inadera3The Japan Environment and Children’s Study (JECS) Group4Toyama Regional Center for Japan Environment and Children’s Study, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, JapanToyama Regional Center for Japan Environment and Children’s Study, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, JapanToyama Regional Center for Japan Environment and Children’s Study, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, JapanToyama Regional Center for Japan Environment and Children’s Study, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, JapanJECS Programme Office, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, JapanFetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation and prefrontal cortex lesions; however, whether air-purifier usage, which can reduce indoor PM levels, is related to infant developmental delay remains unknown. We therefore examined the prospective relationship between air-purifier usage during pregnancy and infant developmental delay by analyzing 82,441 mother–infant pairs using a simple yes/no questionnaire. Developmental delays at 6 and 12 months were assessed in five areas using the Ages and Stages Questionnaire, Third Edition. A generalized linear mixed model analysis was used to derive adjusted odds ratios (AORs) and 95% confidence intervals (95% CIs) while controlling for 20 covariates. The analysis revealed that air-purifier usage was associated with developmental delays in fine motor (AOR: 0.91, 95% CI: 0.83–0.99) and problem solving (AOR: 0.83, 95% CI: 0.77–0.90) at 6 months and in communication (AOR: 0.86, 95% CI: 0.79–0.93), fine motor (AOR: 0.87, 95% CI: 0.82–0.92), problem solving (AOR: 0.83, 95% CI: 0.77–0.88), and personal–social (AOR: 0.79, 95% CI: 0.72–0.86) at 12 months. In conclusion, a negative association exists between air-purifier usage during pregnancy and infant neurodevelopmental delay that strengthens with time. Our results outline the potential role of air purifiers in inhibiting infant neurodevelopmental delay.https://www.mdpi.com/2077-0383/9/6/1924air purifierair cleanerdevelopmental delaydwelling environmentindoor environmentbirth cohort |
| spellingShingle | Kenta Matsumura Kei Hamazaki Akiko Tsuchida Hidekuni Inadera The Japan Environment and Children’s Study (JECS) Group Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS) Journal of Clinical Medicine air purifier air cleaner developmental delay dwelling environment indoor environment birth cohort |
| title | Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS) |
| title_full | Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS) |
| title_fullStr | Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS) |
| title_full_unstemmed | Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS) |
| title_short | Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS) |
| title_sort | prospective association of air purifier usage during pregnancy with infant neurodevelopment a nationwide longitudinal study japan environment and children s study jecs |
| topic | air purifier air cleaner developmental delay dwelling environment indoor environment birth cohort |
| url | https://www.mdpi.com/2077-0383/9/6/1924 |
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