Sinulariolide Suppresses Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase through the PI3K/AKT/mTOR Signaling Pathway in Human Bladder Cancer Cells

Sinulariolide Suppresses Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase through the PI3K/AKT/mTOR Signaling Pathway in Human Bladder Cancer Cells

Sinulariolide is a natural product extracted from the cultured-type soft coral Sinularia flexibilis, and possesses bioactivity against the movement of several types of cancer cells. However, the molecular pathway behind its effects on human bladder cancer remain poorly understood. Using a human blad...

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Bibliographic Details
Main Authors: Te-Chih Cheng, Zhong-Hao Din, Jui-Hsin Su, Yu-Jen Wu, Chih-I Liu
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Marine Drugs
Subjects:
sinulariolide
human bladder cancer
migration
invasion
PI3K/AKT/mTOR signaling pathway
Online Access:https://www.mdpi.com/1660-3397/15/8/238

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