The use of polylactic and polyglycolic copolymer biomaterial in a pre-clinical model of compromised primary stability
Aim Primary implant stability can be compromised by overdrilling of the implant bed. Filling the gap between the implant and the bone with a highly viscous copolymer of polylactic and polyglycolic acid (PLA/PGA) might stabilize the implant and thus supply osseointegration. The aim of this study was...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Ariesdue
2013-03-01
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| Series: | Journal of Osseointegration |
| Subjects: | |
| Online Access: | http://admin.journalofosseointegration.eu/photos/03_07_art_luvizuto_ingl.pdf |
| _version_ | 1818834989222985728 |
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| author | Fernando E. Kayatt Thallita P. Queiroz Rogério Margonar Eloá R. Luvizuto Idelmo R. Garcia-Júnior Roberta Okamoto |
| author_facet | Fernando E. Kayatt Thallita P. Queiroz Rogério Margonar Eloá R. Luvizuto Idelmo R. Garcia-Júnior Roberta Okamoto |
| author_sort | Fernando E. Kayatt |
| collection | DOAJ |
| description | Aim Primary implant stability can be compromised by overdrilling of the implant bed. Filling the gap between the implant and the bone with a highly viscous copolymer of polylactic and polyglycolic acid (PLA/PGA) might stabilize the implant and thus supply osseointegration. The aim of this study was to evaluate implants installed in overdrilled beds associated with PLA/PGA in rats tibia model by means of removal torque test and fluorochrome analysis.Materials and methods For this experiment two groups were selected: in the test group 0.4 mm overdrilled defects (2.0 in diameter and 3 mm long ) were produced in the right tibia of seven rats and implants were placed covered with PLA/PGA biomaterial to fill the gap; the control group was not overdrilled and the implants were placed without the biomaterial. Implants of 1.6 mm in diameter and 3 mm long where placed into all defects. Calcein, alizarin and oxytetracyclin were injected at 7, 15 and 21 postoperative days, respectively, and the animals were sacrificed at 35 postoperative day.Results The results showed that all the implants achieved osseointegration. There were no statistical significance differences in torque-reverse and fluorochrome analysis (P>0.05). Conclusion We can conclude that overdrilled defects filled with PLA/PGA did not disturb osseointegration in this experimental model. |
| first_indexed | 2024-12-19T02:43:34Z |
| format | Article |
| id | doaj.art-dcb24f702a5d45308403c75f1163d517 |
| institution | Directory Open Access Journal |
| issn | 2036-413X 2036-4121 |
| language | English |
| last_indexed | 2024-12-19T02:43:34Z |
| publishDate | 2013-03-01 |
| publisher | Ariesdue |
| record_format | Article |
| series | Journal of Osseointegration |
| spelling | doaj.art-dcb24f702a5d45308403c75f1163d5172022-12-21T20:39:02ZengAriesdueJournal of Osseointegration2036-413X2036-41212013-03-015137The use of polylactic and polyglycolic copolymer biomaterial in a pre-clinical model of compromised primary stabilityFernando E. KayattThallita P. QueirozRogério MargonarEloá R. LuvizutoIdelmo R. Garcia-JúniorRoberta OkamotoAim Primary implant stability can be compromised by overdrilling of the implant bed. Filling the gap between the implant and the bone with a highly viscous copolymer of polylactic and polyglycolic acid (PLA/PGA) might stabilize the implant and thus supply osseointegration. The aim of this study was to evaluate implants installed in overdrilled beds associated with PLA/PGA in rats tibia model by means of removal torque test and fluorochrome analysis.Materials and methods For this experiment two groups were selected: in the test group 0.4 mm overdrilled defects (2.0 in diameter and 3 mm long ) were produced in the right tibia of seven rats and implants were placed covered with PLA/PGA biomaterial to fill the gap; the control group was not overdrilled and the implants were placed without the biomaterial. Implants of 1.6 mm in diameter and 3 mm long where placed into all defects. Calcein, alizarin and oxytetracyclin were injected at 7, 15 and 21 postoperative days, respectively, and the animals were sacrificed at 35 postoperative day.Results The results showed that all the implants achieved osseointegration. There were no statistical significance differences in torque-reverse and fluorochrome analysis (P>0.05). Conclusion We can conclude that overdrilled defects filled with PLA/PGA did not disturb osseointegration in this experimental model.http://admin.journalofosseointegration.eu/photos/03_07_art_luvizuto_ingl.pdfBone remodelingDental implantsFluorochromeOsseointegrationPolylactic acidPolyglycolic acid |
| spellingShingle | Fernando E. Kayatt Thallita P. Queiroz Rogério Margonar Eloá R. Luvizuto Idelmo R. Garcia-Júnior Roberta Okamoto The use of polylactic and polyglycolic copolymer biomaterial in a pre-clinical model of compromised primary stability Journal of Osseointegration Bone remodeling Dental implants Fluorochrome Osseointegration Polylactic acid Polyglycolic acid |
| title | The use of polylactic and polyglycolic copolymer biomaterial in a pre-clinical model of compromised primary stability |
| title_full | The use of polylactic and polyglycolic copolymer biomaterial in a pre-clinical model of compromised primary stability |
| title_fullStr | The use of polylactic and polyglycolic copolymer biomaterial in a pre-clinical model of compromised primary stability |
| title_full_unstemmed | The use of polylactic and polyglycolic copolymer biomaterial in a pre-clinical model of compromised primary stability |
| title_short | The use of polylactic and polyglycolic copolymer biomaterial in a pre-clinical model of compromised primary stability |
| title_sort | use of polylactic and polyglycolic copolymer biomaterial in a pre clinical model of compromised primary stability |
| topic | Bone remodeling Dental implants Fluorochrome Osseointegration Polylactic acid Polyglycolic acid |
| url | http://admin.journalofosseointegration.eu/photos/03_07_art_luvizuto_ingl.pdf |
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