Folic acid, vitamin B12 and homocysteine levels following olanzapine administration in schizophrenia patients
The purpose of this study was to assess the levels of folic acid, vitamin B12 and homocysteine in the serum of schizophrenia patients (n=20) and to evaluate the effect of olanzapine on these biomarkers. The blood was also collected from the 10 healthy volunteers as control. Compared to control, the...
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| Format: | Article |
| Language: | English |
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Bangabandhu Sheikh Mujib Medical University
2018-03-01
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| Series: | Bangabandhu Sheikh Mujib Medical University Journal |
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| Online Access: | https://www.banglajol.info/index.php/BSMMUJ/article/view/34950 |
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| author | Fahmida Hasnat Zesmin F. Dewan Mir Misbahuddin Nargis Akhter Jhunu Shamsunnahar Habiba Akhter Bhuiyan |
| author_facet | Fahmida Hasnat Zesmin F. Dewan Mir Misbahuddin Nargis Akhter Jhunu Shamsunnahar Habiba Akhter Bhuiyan |
| author_sort | Fahmida Hasnat |
| collection | DOAJ |
| description | The purpose of this study was to assess the levels of folic acid, vitamin B12 and homocysteine in the serum of schizophrenia patients (n=20) and to evaluate the effect of olanzapine on these biomarkers. The blood was also collected from the 10 healthy volunteers as control. Compared to control, the serum folic acid (p=0.005) and vitamin B12 levels (p=0.211) were higher in the schizophrenia patients, whereas no difference was evident in the serum homocysteine level. But significantly higher levels of serum folic acid (p=0.005), vitamin B12 (p=0.047) and significantly lower level of serum homocysteine (p=0.000) were observed after 10 weeks of olanzapine administration. BPRS score was reduced significantly after intervention. The Pearson correlation coefficient test showed a statistically not significant negative relationship between the serum folate, vitamin B12 and homocysteine levels. In conclusion, olanzapine can significantly elevate the serum folic acid and vitamin B12 levels whereas it can lower the serum homocysteine level which may contribute to the improvement of symptoms of schizophrenia. |
| first_indexed | 2024-12-12T12:09:08Z |
| format | Article |
| id | doaj.art-dcb65a7996b74164b2701b7e4024e45b |
| institution | Directory Open Access Journal |
| issn | 2074-2908 2224-7750 |
| language | English |
| last_indexed | 2024-12-12T12:09:08Z |
| publishDate | 2018-03-01 |
| publisher | Bangabandhu Sheikh Mujib Medical University |
| record_format | Article |
| series | Bangabandhu Sheikh Mujib Medical University Journal |
| spelling | doaj.art-dcb65a7996b74164b2701b7e4024e45b2022-12-22T00:24:56ZengBangabandhu Sheikh Mujib Medical UniversityBangabandhu Sheikh Mujib Medical University Journal2074-29082224-77502018-03-0111110.3329/bsmmuj.v11i1.3495022922Folic acid, vitamin B12 and homocysteine levels following olanzapine administration in schizophrenia patientsFahmida Hasnat0Zesmin F. Dewan1Mir Misbahuddin2Nargis Akhter3Jhunu Shamsunnahar4Habiba Akhter Bhuiyan5Department of Pharmacology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000Department of Pharmacology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000Department of Pharmacology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000Department of Pharmacology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000Department of Psychiatry, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000Department of Pharmacology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000The purpose of this study was to assess the levels of folic acid, vitamin B12 and homocysteine in the serum of schizophrenia patients (n=20) and to evaluate the effect of olanzapine on these biomarkers. The blood was also collected from the 10 healthy volunteers as control. Compared to control, the serum folic acid (p=0.005) and vitamin B12 levels (p=0.211) were higher in the schizophrenia patients, whereas no difference was evident in the serum homocysteine level. But significantly higher levels of serum folic acid (p=0.005), vitamin B12 (p=0.047) and significantly lower level of serum homocysteine (p=0.000) were observed after 10 weeks of olanzapine administration. BPRS score was reduced significantly after intervention. The Pearson correlation coefficient test showed a statistically not significant negative relationship between the serum folate, vitamin B12 and homocysteine levels. In conclusion, olanzapine can significantly elevate the serum folic acid and vitamin B12 levels whereas it can lower the serum homocysteine level which may contribute to the improvement of symptoms of schizophrenia.https://www.banglajol.info/index.php/BSMMUJ/article/view/34950Folic acidHomocysteineOlanzapineSchizophreniaVitamin B12 |
| spellingShingle | Fahmida Hasnat Zesmin F. Dewan Mir Misbahuddin Nargis Akhter Jhunu Shamsunnahar Habiba Akhter Bhuiyan Folic acid, vitamin B12 and homocysteine levels following olanzapine administration in schizophrenia patients Bangabandhu Sheikh Mujib Medical University Journal Folic acid Homocysteine Olanzapine Schizophrenia Vitamin B12 |
| title | Folic acid, vitamin B12 and homocysteine levels following olanzapine administration in schizophrenia patients |
| title_full | Folic acid, vitamin B12 and homocysteine levels following olanzapine administration in schizophrenia patients |
| title_fullStr | Folic acid, vitamin B12 and homocysteine levels following olanzapine administration in schizophrenia patients |
| title_full_unstemmed | Folic acid, vitamin B12 and homocysteine levels following olanzapine administration in schizophrenia patients |
| title_short | Folic acid, vitamin B12 and homocysteine levels following olanzapine administration in schizophrenia patients |
| title_sort | folic acid vitamin b12 and homocysteine levels following olanzapine administration in schizophrenia patients |
| topic | Folic acid Homocysteine Olanzapine Schizophrenia Vitamin B12 |
| url | https://www.banglajol.info/index.php/BSMMUJ/article/view/34950 |
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