Influence of functional groups on toxicity of carbon nanomaterials
<p>It has been recognized that carbon nanomaterials and soot particles are toxic for human health, but the influence of functionalization on their toxicity as well as the evolution of the toxicity of carbon nanomaterials due to chemical aging in the atmosphere is still controversial. In the cu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Copernicus Publications
2019-06-01
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| Series: | Atmospheric Chemistry and Physics |
| Online Access: | https://www.atmos-chem-phys.net/19/8175/2019/acp-19-8175-2019.pdf |
| Summary: | <p>It has been recognized that carbon nanomaterials and soot particles are
toxic for human health, but the influence
of functionalization on their toxicity as well as the evolution of the
toxicity of carbon nanomaterials due to chemical aging in the atmosphere is still controversial. In
the current study, the oxidation potential measured by dithiothreitol (DTT)
decay rate and the cytotoxicity to murine macrophage cells of different
functionalized carbon nanomaterials were investigated to understand the role
of functionalization in their toxicities. The DTT decay rates of special
black 4A (SB4A), graphene, graphene oxide, single-walled carbon nanotubes
(SWCNTs), SWCNT-OH and SWCNT-COOH were <span class="inline-formula">45.9±3.0</span>, <span class="inline-formula">58.5±6.6</span>,
<span class="inline-formula">160.7±21.7</span>, <span class="inline-formula">38.9±8.9</span>, <span class="inline-formula">57.0±7.2</span> and <span class="inline-formula">36.7±0.2</span> pmol min<span class="inline-formula"><sup>−1</sup></span> <span class="inline-formula">µ</span>g<span class="inline-formula"><sup>−1</sup></span>, respectively. Epoxide was found to be mainly
responsible for the highest DTT decay rate of graphene oxide compared to
other carbon nanomaterials based on comprehensive characterizations. Both
carboxylation and hydroxylation showed little influence on the oxidation
potential of carbon nanomaterials, while epoxidation contributes to the
enhancement of oxidation potential. All these carbon nanomaterials were
toxic to the murine J774 cell line. However, oxidized carbon nanomaterials
(graphene oxide, SWCNT-OH and SWCNT-COOH) showed weaker cytotoxicity to the J774
cell line compared to the corresponding control sample as far as the
metabolic activity was considered and stronger cytotoxicity to the J774 cell
line regarding the membrane integrity and DNA incorporation. These
results imply that epoxidation might enhance the oxidation potential of
carbon nanomaterials.</p> |
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| ISSN: | 1680-7316 1680-7324 |