The Critical Role of TRIB2 in Cancer and Therapy Resistance
The Tribbles pseudokinases family consists of TRIB1, TRIB2, TRIB3 and STK40 and, although evolutionarily conserved, they have distinctive characteristics. Tribbles members are expressed in a context and cell compartment-dependent manner. For example, TRIB1 and TRIB2 have potent oncogenic activities...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/11/2701 |
| _version_ | 1797532019795689472 |
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| author | Victor Mayoral-Varo Lucía Jiménez Wolfgang Link |
| author_facet | Victor Mayoral-Varo Lucía Jiménez Wolfgang Link |
| author_sort | Victor Mayoral-Varo |
| collection | DOAJ |
| description | The Tribbles pseudokinases family consists of TRIB1, TRIB2, TRIB3 and STK40 and, although evolutionarily conserved, they have distinctive characteristics. Tribbles members are expressed in a context and cell compartment-dependent manner. For example, TRIB1 and TRIB2 have potent oncogenic activities in vertebrate cells. Since the identification of Tribbles proteins as modulators of multiple signalling pathways, recent studies have linked their expression with several pathologies, including cancer. Tribbles proteins act as protein adaptors involved in the ubiquitin-proteasome degradation system, as they bridge the gap between substrates and E3 ligases. Between TRIB family members, TRIB2 is the most ancestral member of the family. TRIB2 is involved in protein homeostasis regulation of C/EBPα, β-catenin and TCF4. On the other hand, TRIB2 interacts with MAPKK, AKT and NFkB proteins, involved in cell survival, proliferation and immune response. Here, we review the characteristic features of TRIB2 structure and signalling and its role in many cancer subtypes with an emphasis on TRIB2 function in therapy resistance in melanoma, leukemia and glioblastoma. The strong evidence between TRIB2 expression and chemoresistance provides an attractive opportunity for targeting TRIB2. |
| first_indexed | 2024-03-10T10:53:05Z |
| format | Article |
| id | doaj.art-dcb8db9f00c6480b92d3145fa1ec1fd1 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:53:05Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-dcb8db9f00c6480b92d3145fa1ec1fd12023-11-21T22:05:47ZengMDPI AGCancers2072-66942021-05-011311270110.3390/cancers13112701The Critical Role of TRIB2 in Cancer and Therapy ResistanceVictor Mayoral-Varo0Lucía Jiménez1Wolfgang Link2Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, SpainInstituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, SpainInstituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, SpainThe Tribbles pseudokinases family consists of TRIB1, TRIB2, TRIB3 and STK40 and, although evolutionarily conserved, they have distinctive characteristics. Tribbles members are expressed in a context and cell compartment-dependent manner. For example, TRIB1 and TRIB2 have potent oncogenic activities in vertebrate cells. Since the identification of Tribbles proteins as modulators of multiple signalling pathways, recent studies have linked their expression with several pathologies, including cancer. Tribbles proteins act as protein adaptors involved in the ubiquitin-proteasome degradation system, as they bridge the gap between substrates and E3 ligases. Between TRIB family members, TRIB2 is the most ancestral member of the family. TRIB2 is involved in protein homeostasis regulation of C/EBPα, β-catenin and TCF4. On the other hand, TRIB2 interacts with MAPKK, AKT and NFkB proteins, involved in cell survival, proliferation and immune response. Here, we review the characteristic features of TRIB2 structure and signalling and its role in many cancer subtypes with an emphasis on TRIB2 function in therapy resistance in melanoma, leukemia and glioblastoma. The strong evidence between TRIB2 expression and chemoresistance provides an attractive opportunity for targeting TRIB2.https://www.mdpi.com/2072-6694/13/11/2701TRIB2Tribblespseudokinasessignallingcancertherapy resistance |
| spellingShingle | Victor Mayoral-Varo Lucía Jiménez Wolfgang Link The Critical Role of TRIB2 in Cancer and Therapy Resistance Cancers TRIB2 Tribbles pseudokinases signalling cancer therapy resistance |
| title | The Critical Role of TRIB2 in Cancer and Therapy Resistance |
| title_full | The Critical Role of TRIB2 in Cancer and Therapy Resistance |
| title_fullStr | The Critical Role of TRIB2 in Cancer and Therapy Resistance |
| title_full_unstemmed | The Critical Role of TRIB2 in Cancer and Therapy Resistance |
| title_short | The Critical Role of TRIB2 in Cancer and Therapy Resistance |
| title_sort | critical role of trib2 in cancer and therapy resistance |
| topic | TRIB2 Tribbles pseudokinases signalling cancer therapy resistance |
| url | https://www.mdpi.com/2072-6694/13/11/2701 |
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