Radiation-Induced Salivary Gland Dysfunction: Mechanisms, Therapeutics and Future Directions

Radiation-Induced Salivary Gland Dysfunction: Mechanisms, Therapeutics and Future Directions

Salivary glands sustain collateral damage following radiotherapy (RT) to treat cancers of the head and neck, leading to complications, including mucositis, xerostomia and hyposalivation. Despite salivary gland-sparing techniques and modified dosing strategies, long-term hypofunction remains a signif...

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Bibliographic Details
Main Authors: Kimberly J. Jasmer, Kristy E. Gilman, Kevin Muñoz Forti, Gary A. Weisman, Kirsten H. Limesand
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Journal of Clinical Medicine
Subjects:
radiation
hyposalivation
xerostomia
purinergic signaling
bystander effect
saliva
Online Access:https://www.mdpi.com/2077-0383/9/12/4095

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