Fcμ receptor as a Costimulatory Molecule for T Cells
Summary: Fc receptor for IgM (FcμR)-deficient mice display dysregulated function of neutrophils, dendritic cells, and B cells. The relevance of FcμR to human T cells is still unknown. We show that FcμR is mostly stored inside the cell and that surface expression is tightly regulated. Decreased surfa...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-03-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719301949 |
| _version_ | 1818171596175572992 |
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| author | Andreas Meryk Luca Pangrazzi Magdalena Hagen Florian Hatzmann Brigitte Jenewein Bojana Jakic Natascha Hermann-Kleiter Gottfried Baier Juulia Jylhävä Mikko Hurme Klemens Trieb Beatrix Grubeck-Loebenstein |
| author_facet | Andreas Meryk Luca Pangrazzi Magdalena Hagen Florian Hatzmann Brigitte Jenewein Bojana Jakic Natascha Hermann-Kleiter Gottfried Baier Juulia Jylhävä Mikko Hurme Klemens Trieb Beatrix Grubeck-Loebenstein |
| author_sort | Andreas Meryk |
| collection | DOAJ |
| description | Summary: Fc receptor for IgM (FcμR)-deficient mice display dysregulated function of neutrophils, dendritic cells, and B cells. The relevance of FcμR to human T cells is still unknown. We show that FcμR is mostly stored inside the cell and that surface expression is tightly regulated. Decreased surface expression on T cells from elderly individuals is associated with alterations in the methylation pattern of the FCMR gene. Binding and internalization of IgM stimulate transport of FcμR to the cell surface to ensure sustained IgM uptake. Concurrently, IgM accumulates within the cell, and the surface expression of other receptors increases, among them the T cell receptor (TCR) and costimulatory molecules. This leads to enhanced TCR signaling, proliferation, and cytokine release, in response to low, but not high, doses of antigen. Our findings indicate that FcμR is an important regulator of T cell function and reveal an additional mode of interaction between B and T cells. : Meryk et al. demonstrate that uptake of IgM mediated by FcμR expressed on T cells increases the surface expression of TCR and costimulatory molecules to facilitate T cell activation, particularly when antigen concentrations are low. Consequently, FcμR increases TCR signaling, proliferation, and cytokine release. Keywords: FcμR, IgM, T cells, TCR activation |
| first_indexed | 2024-12-11T18:59:14Z |
| format | Article |
| id | doaj.art-dcbb1609c763493884d532e733c0a63b |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T18:59:14Z |
| publishDate | 2019-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-dcbb1609c763493884d532e733c0a63b2022-12-22T00:54:04ZengElsevierCell Reports2211-12472019-03-01261026812691.e5Fcμ receptor as a Costimulatory Molecule for T CellsAndreas Meryk0Luca Pangrazzi1Magdalena Hagen2Florian Hatzmann3Brigitte Jenewein4Bojana Jakic5Natascha Hermann-Kleiter6Gottfried Baier7Juulia Jylhävä8Mikko Hurme9Klemens Trieb10Beatrix Grubeck-Loebenstein11Department of Immunology, Institute for Biomedical Aging Research, University of Innsbruck, 6020 Innsbruck, Austria; Corresponding authorDepartment of Immunology, Institute for Biomedical Aging Research, University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Immunology, Institute for Biomedical Aging Research, University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Immunology, Institute for Biomedical Aging Research, University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Immunology, Institute for Biomedical Aging Research, University of Innsbruck, 6020 Innsbruck, AustriaDivision of Translational Cell Genetics, Medical University of Innsbruck, 6020 Innsbruck, AustriaDivision of Translational Cell Genetics, Medical University of Innsbruck, 6020 Innsbruck, AustriaDivision of Translational Cell Genetics, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, 17177 Stockholm, SwedenFaculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, FinlandDepartment of Orthopedic Surgery, Hospital Wels-Grieskirchen, 4600 Wels, AustriaDepartment of Immunology, Institute for Biomedical Aging Research, University of Innsbruck, 6020 Innsbruck, AustriaSummary: Fc receptor for IgM (FcμR)-deficient mice display dysregulated function of neutrophils, dendritic cells, and B cells. The relevance of FcμR to human T cells is still unknown. We show that FcμR is mostly stored inside the cell and that surface expression is tightly regulated. Decreased surface expression on T cells from elderly individuals is associated with alterations in the methylation pattern of the FCMR gene. Binding and internalization of IgM stimulate transport of FcμR to the cell surface to ensure sustained IgM uptake. Concurrently, IgM accumulates within the cell, and the surface expression of other receptors increases, among them the T cell receptor (TCR) and costimulatory molecules. This leads to enhanced TCR signaling, proliferation, and cytokine release, in response to low, but not high, doses of antigen. Our findings indicate that FcμR is an important regulator of T cell function and reveal an additional mode of interaction between B and T cells. : Meryk et al. demonstrate that uptake of IgM mediated by FcμR expressed on T cells increases the surface expression of TCR and costimulatory molecules to facilitate T cell activation, particularly when antigen concentrations are low. Consequently, FcμR increases TCR signaling, proliferation, and cytokine release. Keywords: FcμR, IgM, T cells, TCR activationhttp://www.sciencedirect.com/science/article/pii/S2211124719301949 |
| spellingShingle | Andreas Meryk Luca Pangrazzi Magdalena Hagen Florian Hatzmann Brigitte Jenewein Bojana Jakic Natascha Hermann-Kleiter Gottfried Baier Juulia Jylhävä Mikko Hurme Klemens Trieb Beatrix Grubeck-Loebenstein Fcμ receptor as a Costimulatory Molecule for T Cells Cell Reports |
| title | Fcμ receptor as a Costimulatory Molecule for T Cells |
| title_full | Fcμ receptor as a Costimulatory Molecule for T Cells |
| title_fullStr | Fcμ receptor as a Costimulatory Molecule for T Cells |
| title_full_unstemmed | Fcμ receptor as a Costimulatory Molecule for T Cells |
| title_short | Fcμ receptor as a Costimulatory Molecule for T Cells |
| title_sort | fcμ receptor as a costimulatory molecule for t cells |
| url | http://www.sciencedirect.com/science/article/pii/S2211124719301949 |
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