Beau’s Lines and COVID-19; A Systematic Review on Their Association
Background: Beau’s lines are transverse grooves in the nail plate that result from transient interruption of the growth of the proximal nail matrix after severe disease. The aim of this study is to systematically report all evidence on the association of Beau’s lines with COVID-19 infection or vacci...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/13/3/265 |
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| author | Aris P. Agouridis Christina Mastori-Kourmpani Polyna Antoniou Paschalis Konstantinou Evangelos C. Rizos Constantinos Tsioutis |
| author_facet | Aris P. Agouridis Christina Mastori-Kourmpani Polyna Antoniou Paschalis Konstantinou Evangelos C. Rizos Constantinos Tsioutis |
| author_sort | Aris P. Agouridis |
| collection | DOAJ |
| description | Background: Beau’s lines are transverse grooves in the nail plate that result from transient interruption of the growth of the proximal nail matrix after severe disease. The aim of this study is to systematically report all evidence on the association of Beau’s lines with COVID-19 infection or vaccination against COVID-19. Methods: PubMed and Scopus databases were searched up to January 2024 for articles reporting Beau’s lines associated with COVID-19 infection or vaccination for COVID-19. PROSPERO ID: CRD42024496830. Results: PubMed search identified 299 records while Scopus search identified 18 records. After screening the bibliography, nine studies including 35 cases were included in our systematic review. The studies were reported from different areas around the world. Included studies documented Beau’s lines following COVID-19 vaccination (two studies) or after COVID-19 infection (seven studies). High variability was recorded in onset and resolution times among included cases, averaging 3 months and 6 months after COVID-19 infection, respectively. In the two studies reporting Beau’s lines after vaccination, onset was at 7 days and 6 weeks and resolution occurred after 8 and 17 weeks, respectively. Conclusions: To the best of our knowledge, this is the first systematic review reporting the association of Beau’s lines with COVID-19 infection and vaccination. Severe immune response can result in the formation of these nail disorders. Of importance, Beau’s lines represent a potential indicator of prior severe COVID-19 infection or vaccination for COVID-19, as well as a sign of long COVID-19 syndrome. |
| first_indexed | 2024-04-24T17:56:37Z |
| format | Article |
| id | doaj.art-dcbead6435b544119bf0476193ebb25f |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-24T17:56:37Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-dcbead6435b544119bf0476193ebb25f2024-03-27T13:59:00ZengMDPI AGPathogens2076-08172024-03-0113326510.3390/pathogens13030265Beau’s Lines and COVID-19; A Systematic Review on Their AssociationAris P. Agouridis0Christina Mastori-Kourmpani1Polyna Antoniou2Paschalis Konstantinou3Evangelos C. Rizos4Constantinos Tsioutis5School of Medicine, European University Cyprus, 2404 Nicosia, CyprusSchool of Medicine, European University Cyprus, 2404 Nicosia, CyprusSchool of Medicine, European University Cyprus, 2404 Nicosia, CyprusSchool of Medicine, European University Cyprus, 2404 Nicosia, CyprusSchool of Medicine, European University Cyprus, 2404 Nicosia, CyprusSchool of Medicine, European University Cyprus, 2404 Nicosia, CyprusBackground: Beau’s lines are transverse grooves in the nail plate that result from transient interruption of the growth of the proximal nail matrix after severe disease. The aim of this study is to systematically report all evidence on the association of Beau’s lines with COVID-19 infection or vaccination against COVID-19. Methods: PubMed and Scopus databases were searched up to January 2024 for articles reporting Beau’s lines associated with COVID-19 infection or vaccination for COVID-19. PROSPERO ID: CRD42024496830. Results: PubMed search identified 299 records while Scopus search identified 18 records. After screening the bibliography, nine studies including 35 cases were included in our systematic review. The studies were reported from different areas around the world. Included studies documented Beau’s lines following COVID-19 vaccination (two studies) or after COVID-19 infection (seven studies). High variability was recorded in onset and resolution times among included cases, averaging 3 months and 6 months after COVID-19 infection, respectively. In the two studies reporting Beau’s lines after vaccination, onset was at 7 days and 6 weeks and resolution occurred after 8 and 17 weeks, respectively. Conclusions: To the best of our knowledge, this is the first systematic review reporting the association of Beau’s lines with COVID-19 infection and vaccination. Severe immune response can result in the formation of these nail disorders. Of importance, Beau’s lines represent a potential indicator of prior severe COVID-19 infection or vaccination for COVID-19, as well as a sign of long COVID-19 syndrome.https://www.mdpi.com/2076-0817/13/3/265Beau’s linesCOVID-19SARS-CoV-2vaccinationnailsskin |
| spellingShingle | Aris P. Agouridis Christina Mastori-Kourmpani Polyna Antoniou Paschalis Konstantinou Evangelos C. Rizos Constantinos Tsioutis Beau’s Lines and COVID-19; A Systematic Review on Their Association Pathogens Beau’s lines COVID-19 SARS-CoV-2 vaccination nails skin |
| title | Beau’s Lines and COVID-19; A Systematic Review on Their Association |
| title_full | Beau’s Lines and COVID-19; A Systematic Review on Their Association |
| title_fullStr | Beau’s Lines and COVID-19; A Systematic Review on Their Association |
| title_full_unstemmed | Beau’s Lines and COVID-19; A Systematic Review on Their Association |
| title_short | Beau’s Lines and COVID-19; A Systematic Review on Their Association |
| title_sort | beau s lines and covid 19 a systematic review on their association |
| topic | Beau’s lines COVID-19 SARS-CoV-2 vaccination nails skin |
| url | https://www.mdpi.com/2076-0817/13/3/265 |
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