Sulfated Polysaccharides as a Fighter with Protein Non-Physiological Aggregation: The Role of Polysaccharide Flexibility and Charge Density

Sulfated Polysaccharides as a Fighter with Protein Non-Physiological Aggregation: The Role of Polysaccharide Flexibility and Charge Density

Proteins can lose native functionality due to non-physiological aggregation. In this work, we have shown the power of sulfated polysaccharides as a natural assistant to restore damaged protein structures. Protein aggregates enriched by cross-β structures are a characteristic of amyloid fibrils relat...

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Bibliographic Details
Main Authors: Olga N. Makshakova, Liliya R. Bogdanova, Dzhigangir A. Faizullin, Elena A. Ermakova, Yuriy F. Zuev
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
hen egg white lysozyme
amyloid fibrils
sulfated polysaccharides
chaperons
disaggregation effect
protein renaturation
Online Access:https://www.mdpi.com/1422-0067/24/22/16223

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