Coronavirus disease 2019 and gastrointestinal disorders in children
During the past 3 years, the coronavirus disease 2019 (COVID-19) pandemic has had a great impact on people all over the world. However, it has become evident that disease manifestations and severity differ across age groups. Most children have a milder disease course than adults but possibly more pr...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-06-01
|
| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/17562848231177612 |
| _version_ | 1797810813039280128 |
|---|---|
| author | Anna Röckert Tjernberg Petter Malmborg Karl Mårild |
| author_facet | Anna Röckert Tjernberg Petter Malmborg Karl Mårild |
| author_sort | Anna Röckert Tjernberg |
| collection | DOAJ |
| description | During the past 3 years, the coronavirus disease 2019 (COVID-19) pandemic has had a great impact on people all over the world. However, it has become evident that disease manifestations and severity differ across age groups. Most children have a milder disease course than adults but possibly more pronounced gastrointestinal (GI) symptoms. Given the child’s developing immune system, the impact of COVID-19 on disease development may differ compared to adults. This study reviews the potential bi-directional relationship between COVID-19 and GI diseases in children, focusing on common pediatric conditions such as functional GI disorders (FGID), celiac disease (CeD), and inflammatory bowel disease (IBD). Children with GI diseases, in general, and CeD and IBD, in particular, do not seem to have an increased risk of severe COVID-19, including risks of hospitalization, critical care need, and death. While infections are considered candidate environmental factors in both CeD and IBD pathogenesis, and specific infectious agents are known triggers for FGID, there is still not sufficient evidence to implicate COVID-19 in the development of either of these diseases. However, given the scarcity of data and the possible latency period between environmental triggers and disease development, future investigations in this field are warranted. |
| first_indexed | 2024-03-13T07:14:23Z |
| format | Article |
| id | doaj.art-dcbf8023011b4617b45b2332b444142d |
| institution | Directory Open Access Journal |
| issn | 1756-2848 |
| language | English |
| last_indexed | 2024-03-13T07:14:23Z |
| publishDate | 2023-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj.art-dcbf8023011b4617b45b2332b444142d2023-06-05T14:03:25ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482023-06-011610.1177/17562848231177612Coronavirus disease 2019 and gastrointestinal disorders in childrenAnna Röckert TjernbergPetter MalmborgKarl MårildDuring the past 3 years, the coronavirus disease 2019 (COVID-19) pandemic has had a great impact on people all over the world. However, it has become evident that disease manifestations and severity differ across age groups. Most children have a milder disease course than adults but possibly more pronounced gastrointestinal (GI) symptoms. Given the child’s developing immune system, the impact of COVID-19 on disease development may differ compared to adults. This study reviews the potential bi-directional relationship between COVID-19 and GI diseases in children, focusing on common pediatric conditions such as functional GI disorders (FGID), celiac disease (CeD), and inflammatory bowel disease (IBD). Children with GI diseases, in general, and CeD and IBD, in particular, do not seem to have an increased risk of severe COVID-19, including risks of hospitalization, critical care need, and death. While infections are considered candidate environmental factors in both CeD and IBD pathogenesis, and specific infectious agents are known triggers for FGID, there is still not sufficient evidence to implicate COVID-19 in the development of either of these diseases. However, given the scarcity of data and the possible latency period between environmental triggers and disease development, future investigations in this field are warranted.https://doi.org/10.1177/17562848231177612 |
| spellingShingle | Anna Röckert Tjernberg Petter Malmborg Karl Mårild Coronavirus disease 2019 and gastrointestinal disorders in children Therapeutic Advances in Gastroenterology |
| title | Coronavirus disease 2019 and gastrointestinal disorders in children |
| title_full | Coronavirus disease 2019 and gastrointestinal disorders in children |
| title_fullStr | Coronavirus disease 2019 and gastrointestinal disorders in children |
| title_full_unstemmed | Coronavirus disease 2019 and gastrointestinal disorders in children |
| title_short | Coronavirus disease 2019 and gastrointestinal disorders in children |
| title_sort | coronavirus disease 2019 and gastrointestinal disorders in children |
| url | https://doi.org/10.1177/17562848231177612 |
| work_keys_str_mv | AT annarockerttjernberg coronavirusdisease2019andgastrointestinaldisordersinchildren AT pettermalmborg coronavirusdisease2019andgastrointestinaldisordersinchildren AT karlmarild coronavirusdisease2019andgastrointestinaldisordersinchildren |