Polycomb Assemblies Multitask to Regulate Transcription
The Polycomb system is made of an evolutionary ancient group of proteins, present throughout plants and animals. Known initially from developmental studies with the fly <i>Drosophila melanogaster</i>, they were associated with stable sustainment of gene repression and maintenance of cell...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Epigenomes |
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| Online Access: | https://www.mdpi.com/2075-4655/3/2/12 |
| _version_ | 1797758732212371456 |
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| author | Miguel Vidal |
| author_facet | Miguel Vidal |
| author_sort | Miguel Vidal |
| collection | DOAJ |
| description | The Polycomb system is made of an evolutionary ancient group of proteins, present throughout plants and animals. Known initially from developmental studies with the fly <i>Drosophila melanogaster</i>, they were associated with stable sustainment of gene repression and maintenance of cell identity. Acting as multiprotein assemblies with an ability to modify chromatin, through chemical additions to histones and organization of topological domains, they have been involved subsequently in control of developmental transitions and in cell homeostasis. Recent work has unveiled an association of Polycomb components with transcriptionally active loci and the promotion of gene expression, in clear contrast with conventional recognition as repressors. Focusing on mammalian models, I review here advances concerning roles in transcriptional control. Among new findings highlighted is the regulation of their catalytic properties, recruiting to targets, and activities in chromatin organization and compartmentalization. The need for a more integrated approach to the study of the Polycomb system, given its fundamental complexity and its adaptation to cell context, is discussed. |
| first_indexed | 2024-03-12T18:34:21Z |
| format | Article |
| id | doaj.art-dcc09beeda3640d29b554893fb65b5f5 |
| institution | Directory Open Access Journal |
| issn | 2075-4655 |
| language | English |
| last_indexed | 2024-03-12T18:34:21Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Epigenomes |
| spelling | doaj.art-dcc09beeda3640d29b554893fb65b5f52023-08-02T08:09:08ZengMDPI AGEpigenomes2075-46552019-06-01321210.3390/epigenomes3020012epigenomes3020012Polycomb Assemblies Multitask to Regulate TranscriptionMiguel Vidal0Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, Ramiro de Maeztu 9, 28040 Madrid, SpainThe Polycomb system is made of an evolutionary ancient group of proteins, present throughout plants and animals. Known initially from developmental studies with the fly <i>Drosophila melanogaster</i>, they were associated with stable sustainment of gene repression and maintenance of cell identity. Acting as multiprotein assemblies with an ability to modify chromatin, through chemical additions to histones and organization of topological domains, they have been involved subsequently in control of developmental transitions and in cell homeostasis. Recent work has unveiled an association of Polycomb components with transcriptionally active loci and the promotion of gene expression, in clear contrast with conventional recognition as repressors. Focusing on mammalian models, I review here advances concerning roles in transcriptional control. Among new findings highlighted is the regulation of their catalytic properties, recruiting to targets, and activities in chromatin organization and compartmentalization. The need for a more integrated approach to the study of the Polycomb system, given its fundamental complexity and its adaptation to cell context, is discussed.https://www.mdpi.com/2075-4655/3/2/12Polycombchromatin modifierPRC1PRC2transcriptional repressionhistone E3 ligasehistone lysine methyltransferasechromatin topologynuclear condensatesDNA binding |
| spellingShingle | Miguel Vidal Polycomb Assemblies Multitask to Regulate Transcription Epigenomes Polycomb chromatin modifier PRC1 PRC2 transcriptional repression histone E3 ligase histone lysine methyltransferase chromatin topology nuclear condensates DNA binding |
| title | Polycomb Assemblies Multitask to Regulate Transcription |
| title_full | Polycomb Assemblies Multitask to Regulate Transcription |
| title_fullStr | Polycomb Assemblies Multitask to Regulate Transcription |
| title_full_unstemmed | Polycomb Assemblies Multitask to Regulate Transcription |
| title_short | Polycomb Assemblies Multitask to Regulate Transcription |
| title_sort | polycomb assemblies multitask to regulate transcription |
| topic | Polycomb chromatin modifier PRC1 PRC2 transcriptional repression histone E3 ligase histone lysine methyltransferase chromatin topology nuclear condensates DNA binding |
| url | https://www.mdpi.com/2075-4655/3/2/12 |
| work_keys_str_mv | AT miguelvidal polycombassembliesmultitasktoregulatetranscription |