Bilateral Phyllodes Giant Tumor. A Case Report Analyzed by Array-CGH
The breast phyllodes tumor is a biphasic tumor that accounts for less than of 1% of all breast neoplasms. It is classified as benign, borderline, or malignant, and can mimic benign masses. Some recurrent alterations have been identified. However, a precise molecular classification of these tumors ha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/10/825 |
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| author | Francesco Fortarezza Federica Pezzuto Gerardo Cazzato Clelia Punzo Antonio d’Amati Teresa Lettini Mattia Gentile Antonia Lucia Buonadonna Marta Mariano Angela Pezzolla Gabriella Serio |
| author_facet | Francesco Fortarezza Federica Pezzuto Gerardo Cazzato Clelia Punzo Antonio d’Amati Teresa Lettini Mattia Gentile Antonia Lucia Buonadonna Marta Mariano Angela Pezzolla Gabriella Serio |
| author_sort | Francesco Fortarezza |
| collection | DOAJ |
| description | The breast phyllodes tumor is a biphasic tumor that accounts for less than of 1% of all breast neoplasms. It is classified as benign, borderline, or malignant, and can mimic benign masses. Some recurrent alterations have been identified. However, a precise molecular classification of these tumors has not yet been established. Herein, we describe a case of a 43-year-old woman that was admitted to the emergency room for a significant bleeding from the breast skin. A voluminous ulcerative mass of the left breast and multiple nodules with micro-calcifications on the right side were detected at a physical examination. A left total mastectomy and a nodulectomy of the right breast was performed. The histological diagnosis of the surgical specimens reported a bilateral giant phyllodes tumor, showing malignant features on the left and borderline characteristics associated with a fibroadenoma on the right. A further molecular analysis was carried out by an array-Comparative Genomic Hybridization (CGH) to characterize copy-number alterations. Many losses were detected in the malignant mass, involving several tumor suppressor genes. These findings could explain the malignant growth and the metastatic risk. In our study, genomic profiling by an array-CGH revealed a greater chromosomal instability in the borderline mass (40 total defects) than in the malignant (19 total defects) giant phyllodes tumor, reflecting the tumor heterogeneity. Should our results be confirmed with more sensitive and specific molecular tests (DNA sequencing and FISH analysis), they could allow a better selection of patients with adverse pathological features, thus optimizing and improving patient’s management. |
| first_indexed | 2024-03-10T15:37:56Z |
| format | Article |
| id | doaj.art-dcc190b6cb494c7487d87ab9b76f67e5 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T15:37:56Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-dcc190b6cb494c7487d87ab9b76f67e52023-11-20T17:09:25ZengMDPI AGDiagnostics2075-44182020-10-01101082510.3390/diagnostics10100825Bilateral Phyllodes Giant Tumor. A Case Report Analyzed by Array-CGHFrancesco Fortarezza0Federica Pezzuto1Gerardo Cazzato2Clelia Punzo3Antonio d’Amati4Teresa Lettini5Mattia Gentile6Antonia Lucia Buonadonna7Marta Mariano8Angela Pezzolla9Gabriella Serio10Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Pathology Unit, University of Padova, 35121 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, Pathology Unit, University of Padova, 35121 Padova, ItalyDepartment of Emergency and Organ Transplantation (DETO), Pathology Section, Breast Unit Care, University of Bari, Medical School, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Surgery Section, Breast Unit Care, University of Bari, Medical School, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Pathology Section, Breast Unit Care, University of Bari, Medical School, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Pathology Section, Breast Unit Care, University of Bari, Medical School, 70124 Bari, ItalyMedical Genetics, “Di Venere” Hospital, 70131 Carbonara (Bari), ItalyMedical Genetics, “Di Venere” Hospital, 70131 Carbonara (Bari), ItalyDepartment of Emergency and Organ Transplantation (DETO), Pathology Section, Breast Unit Care, University of Bari, Medical School, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Surgery Section, Breast Unit Care, University of Bari, Medical School, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Pathology Section, Breast Unit Care, University of Bari, Medical School, 70124 Bari, ItalyThe breast phyllodes tumor is a biphasic tumor that accounts for less than of 1% of all breast neoplasms. It is classified as benign, borderline, or malignant, and can mimic benign masses. Some recurrent alterations have been identified. However, a precise molecular classification of these tumors has not yet been established. Herein, we describe a case of a 43-year-old woman that was admitted to the emergency room for a significant bleeding from the breast skin. A voluminous ulcerative mass of the left breast and multiple nodules with micro-calcifications on the right side were detected at a physical examination. A left total mastectomy and a nodulectomy of the right breast was performed. The histological diagnosis of the surgical specimens reported a bilateral giant phyllodes tumor, showing malignant features on the left and borderline characteristics associated with a fibroadenoma on the right. A further molecular analysis was carried out by an array-Comparative Genomic Hybridization (CGH) to characterize copy-number alterations. Many losses were detected in the malignant mass, involving several tumor suppressor genes. These findings could explain the malignant growth and the metastatic risk. In our study, genomic profiling by an array-CGH revealed a greater chromosomal instability in the borderline mass (40 total defects) than in the malignant (19 total defects) giant phyllodes tumor, reflecting the tumor heterogeneity. Should our results be confirmed with more sensitive and specific molecular tests (DNA sequencing and FISH analysis), they could allow a better selection of patients with adverse pathological features, thus optimizing and improving patient’s management.https://www.mdpi.com/2075-4418/10/10/825breast tumorphyllodes tumorarray-CGH |
| spellingShingle | Francesco Fortarezza Federica Pezzuto Gerardo Cazzato Clelia Punzo Antonio d’Amati Teresa Lettini Mattia Gentile Antonia Lucia Buonadonna Marta Mariano Angela Pezzolla Gabriella Serio Bilateral Phyllodes Giant Tumor. A Case Report Analyzed by Array-CGH Diagnostics breast tumor phyllodes tumor array-CGH |
| title | Bilateral Phyllodes Giant Tumor. A Case Report Analyzed by Array-CGH |
| title_full | Bilateral Phyllodes Giant Tumor. A Case Report Analyzed by Array-CGH |
| title_fullStr | Bilateral Phyllodes Giant Tumor. A Case Report Analyzed by Array-CGH |
| title_full_unstemmed | Bilateral Phyllodes Giant Tumor. A Case Report Analyzed by Array-CGH |
| title_short | Bilateral Phyllodes Giant Tumor. A Case Report Analyzed by Array-CGH |
| title_sort | bilateral phyllodes giant tumor a case report analyzed by array cgh |
| topic | breast tumor phyllodes tumor array-CGH |
| url | https://www.mdpi.com/2075-4418/10/10/825 |
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