The use of diffusion-tensor imaging to assess microstructural integrity of white matter of patients with Alzheimer’s disease
Objective. To compare diffusion-tensor imaging (DTI) measures in different anatomic regions of the brain in patients with an isolated Alzheimer's disease (AD) and patients with AD and small-vessel disease (SVD).Material and methods. 20 AD patients, aged 66 (±10), of whom 11 AD patients had an i...
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| Format: | Article |
| Language: | English |
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Luchevaya Diagnostika, LLC
2019-01-01
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| Series: | Вестник рентгенологии и радиологии |
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| Online Access: | https://www.russianradiology.ru/jour/article/view/396 |
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| author | V. A. Perepelov V. I. Solodovnikov V. E. Sinitsyn E. M. Perepelova N. N. Koberskaya V. N. Gridin N. N. Yakhno |
| author_facet | V. A. Perepelov V. I. Solodovnikov V. E. Sinitsyn E. M. Perepelova N. N. Koberskaya V. N. Gridin N. N. Yakhno |
| author_sort | V. A. Perepelov |
| collection | DOAJ |
| description | Objective. To compare diffusion-tensor imaging (DTI) measures in different anatomic regions of the brain in patients with an isolated Alzheimer's disease (AD) and patients with AD and small-vessel disease (SVD).Material and methods. 20 AD patients, aged 66 (±10), of whom 11 AD patients had an isolated neurodegenerative process and 9 patients, who were diagnosed with AD+SVD, were examined. A research was made on a 3 T Siemens Magnetom Skyra MR-scanner. All participants underwent the same imaging protocol, which included standard clinical- and diffusion tensor pulse sequences. With an MR-image processing software package Olea Medical Sphere 3.0, fractional anisotropy (FA), mean diffusivity (MD), axial and radial diffusivity (AxD and RxD) were measured in different brain regions.Results. Significant differences in DTI measures (FA, MD, AxD, RxD), indicating more severe white matter microstructural damage in AD+SVD patients, compared with patients with an isolated AD, were observed in middle thalamic radiation, upper and lower longitudinal bundles, posterior part of cingulate gyrus and genu of corpus callosum.Conclusion. DTI is an informative method, highly sensitive in detecting difference in white matter microstructural integrity of brain tissue in individuals with an isolated AD and patients with AD+SVD. |
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| institution | Directory Open Access Journal |
| issn | 0042-4676 2619-0478 |
| language | English |
| last_indexed | 2025-03-14T16:31:36Z |
| publishDate | 2019-01-01 |
| publisher | Luchevaya Diagnostika, LLC |
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| series | Вестник рентгенологии и радиологии |
| spelling | doaj.art-dcc2e6b6b07644ceb2698bb3919c667d2025-02-21T12:05:28ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782019-01-0199629530410.20862/0042-4676-2018-99-6-295-304262The use of diffusion-tensor imaging to assess microstructural integrity of white matter of patients with Alzheimer’s diseaseV. A. Perepelov0V. I. Solodovnikov1V. E. Sinitsyn2E. M. Perepelova3N. N. Koberskaya4V. N. Gridin5N. N. Yakhno6I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian FederationCenter of Information Technologies in Design, Russian Academy of SciencesLomonosov Moscow State University; Russian Medical Academy of Сontinuous Professional Education, Ministry of Health of Russian FederationI.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian FederationI.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian FederationCenter of Information Technologies in Design, Russian Academy of SciencesI.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian FederationObjective. To compare diffusion-tensor imaging (DTI) measures in different anatomic regions of the brain in patients with an isolated Alzheimer's disease (AD) and patients with AD and small-vessel disease (SVD).Material and methods. 20 AD patients, aged 66 (±10), of whom 11 AD patients had an isolated neurodegenerative process and 9 patients, who were diagnosed with AD+SVD, were examined. A research was made on a 3 T Siemens Magnetom Skyra MR-scanner. All participants underwent the same imaging protocol, which included standard clinical- and diffusion tensor pulse sequences. With an MR-image processing software package Olea Medical Sphere 3.0, fractional anisotropy (FA), mean diffusivity (MD), axial and radial diffusivity (AxD and RxD) were measured in different brain regions.Results. Significant differences in DTI measures (FA, MD, AxD, RxD), indicating more severe white matter microstructural damage in AD+SVD patients, compared with patients with an isolated AD, were observed in middle thalamic radiation, upper and lower longitudinal bundles, posterior part of cingulate gyrus and genu of corpus callosum.Conclusion. DTI is an informative method, highly sensitive in detecting difference in white matter microstructural integrity of brain tissue in individuals with an isolated AD and patients with AD+SVD.https://www.russianradiology.ru/jour/article/view/396dementiaalzheimer's diseasesmall-vessel diseasemagnetic resonance imagingdiffusion-tensor imaging |
| spellingShingle | V. A. Perepelov V. I. Solodovnikov V. E. Sinitsyn E. M. Perepelova N. N. Koberskaya V. N. Gridin N. N. Yakhno The use of diffusion-tensor imaging to assess microstructural integrity of white matter of patients with Alzheimer’s disease Вестник рентгенологии и радиологии dementia alzheimer's disease small-vessel disease magnetic resonance imaging diffusion-tensor imaging |
| title | The use of diffusion-tensor imaging to assess microstructural integrity of white matter of patients with Alzheimer’s disease |
| title_full | The use of diffusion-tensor imaging to assess microstructural integrity of white matter of patients with Alzheimer’s disease |
| title_fullStr | The use of diffusion-tensor imaging to assess microstructural integrity of white matter of patients with Alzheimer’s disease |
| title_full_unstemmed | The use of diffusion-tensor imaging to assess microstructural integrity of white matter of patients with Alzheimer’s disease |
| title_short | The use of diffusion-tensor imaging to assess microstructural integrity of white matter of patients with Alzheimer’s disease |
| title_sort | use of diffusion tensor imaging to assess microstructural integrity of white matter of patients with alzheimer s disease |
| topic | dementia alzheimer's disease small-vessel disease magnetic resonance imaging diffusion-tensor imaging |
| url | https://www.russianradiology.ru/jour/article/view/396 |
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