Fast association tests for genes with FAST.
<h4>Unlabelled</h4>Gene-based tests of association can increase the power of a genome-wide association study by aggregating multiple independent effects across a gene or locus into a single stronger signal. Recent gene-based tests have distinct approaches to selecting which variants to a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23935874/?tool=EBI |
| _version_ | 1818574402544992256 |
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| author | Pritam Chanda Hailiang Huang Dan E Arking Joel S Bader |
| author_facet | Pritam Chanda Hailiang Huang Dan E Arking Joel S Bader |
| author_sort | Pritam Chanda |
| collection | DOAJ |
| description | <h4>Unlabelled</h4>Gene-based tests of association can increase the power of a genome-wide association study by aggregating multiple independent effects across a gene or locus into a single stronger signal. Recent gene-based tests have distinct approaches to selecting which variants to aggregate within a locus, modeling the effects of linkage disequilibrium, representing fractional allele counts from imputation, and managing permutation tests for p-values. Implementing these tests in a single, efficient framework has great practical value. Fast ASsociation Tests (Fast) addresses this need by implementing leading gene-based association tests together with conventional SNP-based univariate tests and providing a consolidated, easily interpreted report. Fast scales readily to genome-wide SNP data with millions of SNPs and tens of thousands of individuals, provides implementations that are orders of magnitude faster than original literature reports, and provides a unified framework for performing several gene based association tests concurrently and efficiently on the same data.<h4>Availability</h4>https://bitbucket.org/baderlab/fast/downloads/FAST.tar.gz, with documentation at https://bitbucket.org/baderlab/fast/wiki/Home. |
| first_indexed | 2024-12-15T00:26:11Z |
| format | Article |
| id | doaj.art-dcc3585dd4f3404b844d0650ff3f2444 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-15T00:26:11Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dcc3585dd4f3404b844d0650ff3f24442022-12-21T22:42:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6858510.1371/journal.pone.0068585Fast association tests for genes with FAST.Pritam ChandaHailiang HuangDan E ArkingJoel S Bader<h4>Unlabelled</h4>Gene-based tests of association can increase the power of a genome-wide association study by aggregating multiple independent effects across a gene or locus into a single stronger signal. Recent gene-based tests have distinct approaches to selecting which variants to aggregate within a locus, modeling the effects of linkage disequilibrium, representing fractional allele counts from imputation, and managing permutation tests for p-values. Implementing these tests in a single, efficient framework has great practical value. Fast ASsociation Tests (Fast) addresses this need by implementing leading gene-based association tests together with conventional SNP-based univariate tests and providing a consolidated, easily interpreted report. Fast scales readily to genome-wide SNP data with millions of SNPs and tens of thousands of individuals, provides implementations that are orders of magnitude faster than original literature reports, and provides a unified framework for performing several gene based association tests concurrently and efficiently on the same data.<h4>Availability</h4>https://bitbucket.org/baderlab/fast/downloads/FAST.tar.gz, with documentation at https://bitbucket.org/baderlab/fast/wiki/Home.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23935874/?tool=EBI |
| spellingShingle | Pritam Chanda Hailiang Huang Dan E Arking Joel S Bader Fast association tests for genes with FAST. PLoS ONE |
| title | Fast association tests for genes with FAST. |
| title_full | Fast association tests for genes with FAST. |
| title_fullStr | Fast association tests for genes with FAST. |
| title_full_unstemmed | Fast association tests for genes with FAST. |
| title_short | Fast association tests for genes with FAST. |
| title_sort | fast association tests for genes with fast |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23935874/?tool=EBI |
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