The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis
Ferroptosis is a new type of cell death caused by iron-dependent lipid peroxidation. In recent years, it has been found that ferroptosis can promote the progression of atherosclerosis (AS). Macrophages have been proven to play multiple roles in the occurrence and development of AS. Iron is a necessa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/11/1702 |
| _version_ | 1827644892421029888 |
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| author | Jiedong Ma Hongqi Zhang Yufei Chen Xiaojin Liu Jiamin Tian Wei Shen |
| author_facet | Jiedong Ma Hongqi Zhang Yufei Chen Xiaojin Liu Jiamin Tian Wei Shen |
| author_sort | Jiedong Ma |
| collection | DOAJ |
| description | Ferroptosis is a new type of cell death caused by iron-dependent lipid peroxidation. In recent years, it has been found that ferroptosis can promote the progression of atherosclerosis (AS). Macrophages have been proven to play multiple roles in the occurrence and development of AS. Iron is a necessary mineral that participates in different functions of macrophages under physiological conditions. But iron overload and ferroptosis in macrophages may promote the progression of AS. Herein, we summarize the role of iron overload and ferroptosis in macrophages in AS from the perspective of iron metabolism, and iron overload and ferroptosis are significant contributors to AS development. |
| first_indexed | 2024-03-09T18:27:50Z |
| format | Article |
| id | doaj.art-dcc52b68a3d74719b08683c7c1f187ef |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T18:27:50Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-dcc52b68a3d74719b08683c7c1f187ef2023-11-24T07:48:08ZengMDPI AGBiomolecules2218-273X2022-11-011211170210.3390/biom12111702The Role of Macrophage Iron Overload and Ferroptosis in AtherosclerosisJiedong Ma0Hongqi Zhang1Yufei Chen2Xiaojin Liu3Jiamin Tian4Wei Shen5Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaFerroptosis is a new type of cell death caused by iron-dependent lipid peroxidation. In recent years, it has been found that ferroptosis can promote the progression of atherosclerosis (AS). Macrophages have been proven to play multiple roles in the occurrence and development of AS. Iron is a necessary mineral that participates in different functions of macrophages under physiological conditions. But iron overload and ferroptosis in macrophages may promote the progression of AS. Herein, we summarize the role of iron overload and ferroptosis in macrophages in AS from the perspective of iron metabolism, and iron overload and ferroptosis are significant contributors to AS development.https://www.mdpi.com/2218-273X/12/11/1702ferroptosisatherosclerosismacrophagesiron homeostasisiron overload |
| spellingShingle | Jiedong Ma Hongqi Zhang Yufei Chen Xiaojin Liu Jiamin Tian Wei Shen The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis Biomolecules ferroptosis atherosclerosis macrophages iron homeostasis iron overload |
| title | The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis |
| title_full | The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis |
| title_fullStr | The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis |
| title_full_unstemmed | The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis |
| title_short | The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis |
| title_sort | role of macrophage iron overload and ferroptosis in atherosclerosis |
| topic | ferroptosis atherosclerosis macrophages iron homeostasis iron overload |
| url | https://www.mdpi.com/2218-273X/12/11/1702 |
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