A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks

A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks

Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous r...

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Bibliographic Details
Main Authors: Till Bartke, Anja Groth
Format: Article
Language:English
Published: Taylor & Francis Group 2019-07-01
Series:Molecular & Cellular Oncology
Subjects:
brca1
bard1
53bp1
dna double strand break repair
homologous recombination
Online Access:http://dx.doi.org/10.1080/23723556.2019.1605820

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