Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage Energies
Combined use of chemotherapy and radiation therapy is commonly used in cancer treatment, but the toxic effects on normal tissue are a major limitation. This study assesses the potential to improve radiation therapy when combining gold nanoparticle (GNP) mediated radiation sensitization with chemorad...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-05-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/10/5/150 |
| _version_ | 1797725769685794816 |
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| author | Celina Yang Kyle Bromma Wonmo Sung Jan Schuemann Devika Chithrani |
| author_facet | Celina Yang Kyle Bromma Wonmo Sung Jan Schuemann Devika Chithrani |
| author_sort | Celina Yang |
| collection | DOAJ |
| description | Combined use of chemotherapy and radiation therapy is commonly used in cancer treatment, but the toxic effects on normal tissue are a major limitation. This study assesses the potential to improve radiation therapy when combining gold nanoparticle (GNP) mediated radiation sensitization with chemoradiation compared to chemoradiation alone. Incorporation of GNPs with 2 Gy, 6 MV (megavoltage) radiation resulted in a 19 ± 6% decrease in survival of MDA-MB-231 cells. Monte-Carlo simulations were performed to assess dosimetric differences in the presence of GNPs in radiation. The results show that physics dosimetry represents a small fraction of the observed effect. The survival fraction of the cells exposed to GNPs, cisplatin, and radiation was 0.16 ± 0.007, while cells treated with cisplatin and radiation only was 0.23 ± 0.011. The presence of GNPs resulted in a 30 ± 6% decrease in the survival, having an additive effect. The concentration of the GNPs and free drug used for this study was 0.3 and 435 nM, respectively. These concentrations are relatively lower and achievable in an in vivo setting. Hence, the results of our study would accelerate the incorporation of GNP-mediated chemoradiation into current cancer therapeutic protocols in the near future. |
| first_indexed | 2024-03-12T10:36:03Z |
| format | Article |
| id | doaj.art-dcc586fb02164c7da9b5297ee648df1d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:36:03Z |
| publishDate | 2018-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-dcc586fb02164c7da9b5297ee648df1d2023-09-02T08:47:46ZengMDPI AGCancers2072-66942018-05-0110515010.3390/cancers10050150cancers10050150Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage EnergiesCelina Yang0Kyle Bromma1Wonmo Sung2Jan Schuemann3Devika Chithrani4Department of Biomedical Physics, Ryerson University, Toronto, ON M5B 2K3, CanadaDepartment of Physics and Astronomy, University of Victoria, Victoria, BC V8P 5C2, CanadaDepartment of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USADepartment of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USADepartment of Biomedical Physics, Ryerson University, Toronto, ON M5B 2K3, CanadaCombined use of chemotherapy and radiation therapy is commonly used in cancer treatment, but the toxic effects on normal tissue are a major limitation. This study assesses the potential to improve radiation therapy when combining gold nanoparticle (GNP) mediated radiation sensitization with chemoradiation compared to chemoradiation alone. Incorporation of GNPs with 2 Gy, 6 MV (megavoltage) radiation resulted in a 19 ± 6% decrease in survival of MDA-MB-231 cells. Monte-Carlo simulations were performed to assess dosimetric differences in the presence of GNPs in radiation. The results show that physics dosimetry represents a small fraction of the observed effect. The survival fraction of the cells exposed to GNPs, cisplatin, and radiation was 0.16 ± 0.007, while cells treated with cisplatin and radiation only was 0.23 ± 0.011. The presence of GNPs resulted in a 30 ± 6% decrease in the survival, having an additive effect. The concentration of the GNPs and free drug used for this study was 0.3 and 435 nM, respectively. These concentrations are relatively lower and achievable in an in vivo setting. Hence, the results of our study would accelerate the incorporation of GNP-mediated chemoradiation into current cancer therapeutic protocols in the near future.http://www.mdpi.com/2072-6694/10/5/150gold nanoparticles (GNP)cisplatinMonte Carloradiationchemoradiation |
| spellingShingle | Celina Yang Kyle Bromma Wonmo Sung Jan Schuemann Devika Chithrani Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage Energies Cancers gold nanoparticles (GNP) cisplatin Monte Carlo radiation chemoradiation |
| title | Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage Energies |
| title_full | Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage Energies |
| title_fullStr | Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage Energies |
| title_full_unstemmed | Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage Energies |
| title_short | Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage Energies |
| title_sort | determining the radiation enhancement effects of gold nanoparticles in cells in a combined treatment with cisplatin and radiation at therapeutic megavoltage energies |
| topic | gold nanoparticles (GNP) cisplatin Monte Carlo radiation chemoradiation |
| url | http://www.mdpi.com/2072-6694/10/5/150 |
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