Numerical Modeling of Particle Dynamics Inside a Dry Powder Inhaler
The development of novel dry powders for dry powder inhalers (DPIs) requires the in vitro assessment of DPI aerodynamic performance. As a potential complementary method, in silico numerical simulations can provide additional information about the mechanisms that guide the particles and their behavio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/12/2591 |
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| author | Tijana Šušteršič Aleksandar Bodić Jelisaveta Ignjatović Sandra Cvijić Svetlana Ibrić Nenad Filipović |
| author_facet | Tijana Šušteršič Aleksandar Bodić Jelisaveta Ignjatović Sandra Cvijić Svetlana Ibrić Nenad Filipović |
| author_sort | Tijana Šušteršič |
| collection | DOAJ |
| description | The development of novel dry powders for dry powder inhalers (DPIs) requires the in vitro assessment of DPI aerodynamic performance. As a potential complementary method, in silico numerical simulations can provide additional information about the mechanisms that guide the particles and their behavior inside DPIs. The aim of this study was to apply computational fluid dynamics (CFDs) coupled with a discrete phase model (DPM) to describe the forces and particle trajectories inside the RS01<sup>®</sup> as a model DPI device. The methodology included standard fluid flow equations but also additional equations for the particle sticking mechanism, as well as particle behavior after contacting the DPI wall surface, including the particle detachment process. The results show that the coefficient of restitution between the particle and the impact surface does not have a high impact on the results, meaning that all tested combinations gave similar output efficiencies and particle behaviors. No sliding or rolling mechanisms were observed for the particle detachment process, meaning that simple bouncing off or deposition particle behavior is present inside DPIs. The developed methodology can serve as a basis for the additional understanding of the particles’ behavior inside DPIs, which is not possible using only in vitro experiments; this implies the possibility of increasing the efficiency of DPIs. |
| first_indexed | 2024-03-09T15:58:47Z |
| format | Article |
| id | doaj.art-dcc5a8de46654a7fa77180dfcfb7eb7e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:47Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-dcc5a8de46654a7fa77180dfcfb7eb7e2023-11-24T17:18:34ZengMDPI AGPharmaceutics1999-49232022-11-011412259110.3390/pharmaceutics14122591Numerical Modeling of Particle Dynamics Inside a Dry Powder InhalerTijana Šušteršič0Aleksandar Bodić1Jelisaveta Ignjatović2Sandra Cvijić3Svetlana Ibrić4Nenad Filipović5Faculty of Engineering, University of Kragujevac, Sestre Janjić 6, 34000 Kragujevac, SerbiaFaculty of Engineering, University of Kragujevac, Sestre Janjić 6, 34000 Kragujevac, SerbiaDepartment of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, SerbiaFaculty of Engineering, University of Kragujevac, Sestre Janjić 6, 34000 Kragujevac, SerbiaThe development of novel dry powders for dry powder inhalers (DPIs) requires the in vitro assessment of DPI aerodynamic performance. As a potential complementary method, in silico numerical simulations can provide additional information about the mechanisms that guide the particles and their behavior inside DPIs. The aim of this study was to apply computational fluid dynamics (CFDs) coupled with a discrete phase model (DPM) to describe the forces and particle trajectories inside the RS01<sup>®</sup> as a model DPI device. The methodology included standard fluid flow equations but also additional equations for the particle sticking mechanism, as well as particle behavior after contacting the DPI wall surface, including the particle detachment process. The results show that the coefficient of restitution between the particle and the impact surface does not have a high impact on the results, meaning that all tested combinations gave similar output efficiencies and particle behaviors. No sliding or rolling mechanisms were observed for the particle detachment process, meaning that simple bouncing off or deposition particle behavior is present inside DPIs. The developed methodology can serve as a basis for the additional understanding of the particles’ behavior inside DPIs, which is not possible using only in vitro experiments; this implies the possibility of increasing the efficiency of DPIs.https://www.mdpi.com/1999-4923/14/12/2591dry powders inhalers (DPI)computational fluid dynamics (CFD)discrete phase model (DPM)particle stickingDPI efficiency |
| spellingShingle | Tijana Šušteršič Aleksandar Bodić Jelisaveta Ignjatović Sandra Cvijić Svetlana Ibrić Nenad Filipović Numerical Modeling of Particle Dynamics Inside a Dry Powder Inhaler Pharmaceutics dry powders inhalers (DPI) computational fluid dynamics (CFD) discrete phase model (DPM) particle sticking DPI efficiency |
| title | Numerical Modeling of Particle Dynamics Inside a Dry Powder Inhaler |
| title_full | Numerical Modeling of Particle Dynamics Inside a Dry Powder Inhaler |
| title_fullStr | Numerical Modeling of Particle Dynamics Inside a Dry Powder Inhaler |
| title_full_unstemmed | Numerical Modeling of Particle Dynamics Inside a Dry Powder Inhaler |
| title_short | Numerical Modeling of Particle Dynamics Inside a Dry Powder Inhaler |
| title_sort | numerical modeling of particle dynamics inside a dry powder inhaler |
| topic | dry powders inhalers (DPI) computational fluid dynamics (CFD) discrete phase model (DPM) particle sticking DPI efficiency |
| url | https://www.mdpi.com/1999-4923/14/12/2591 |
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