Association between TP53 codon 72 G>C Polymorphism and Thyroid Carcinoma Risk: An Up-to-Date Meta-Analysis
Objective: Many published data on the association between p53 codon 72 G>C polymorphism and thyroid carcinoma risk showed inconclusive results. The aim this study was to assess the association between p53 codon 72 G>C polymorphism and thyroid cancer risk. Methods: A literature search of PubMe...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
West Asia Organization for Cancer Prevention
2016-12-01
|
| Series: | Asian Pacific Journal of Cancer Biology |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcb/article/view/205 |
| _version_ | 1827370422205677568 |
|---|---|
| author | Jamal Jafari Nedooshan Mohammad Forat Yazdi Hossein Neamatzadeh Masoud Zare Shehneh Saeed Kargar Niloofar Seddighi |
| author_facet | Jamal Jafari Nedooshan Mohammad Forat Yazdi Hossein Neamatzadeh Masoud Zare Shehneh Saeed Kargar Niloofar Seddighi |
| author_sort | Jamal Jafari Nedooshan |
| collection | DOAJ |
| description | Objective: Many published data on the association between p53 codon 72 G>C polymorphism and thyroid carcinoma risk showed inconclusive results. The aim this study was to assess the association between p53 codon 72 G>C polymorphism and thyroid cancer risk.
Methods: A literature search of PubMed, EMBASE, Google scholar and Web of Science databases for case–control studies examining the association between p53 codon 72 G>C polymorphism and thyroid cancer susceptibility up October 2016 was performed. Odds ratios (OR) with 95 % confidence intervals (95 % CI) were used to assess the strength of the association.
Results: A total of 12 case–control studies involving 2,062 thyroid cancer patients and 3,027 controls were included. There was a significant association between the p53 codon 72 G>C polymorphism and thyroid cancer susceptibility in the overall populations under homozygote (CC vs. GG: OR = 1.18, 95% CI 1.12-3.05, P = 0.01) and recessive model (CC vs. GC+GG: OR = 1.73, 95% CI 1.16-2.59, P = 0.007). Subgroup analysis by ethnicity showed that there was no significant association between p53 codon 72 G>C polymorphism and thyroid cancer risk in Caucasians, Asians and mixed Brazilian. No significant publication bias was observed by using Begg’s funnel plot and Egger’s test.
Conclusion: Present meta-analysis indicated that the p53 codon 72 G>C polymorphism may be associated with thyroid cancer risk. However, more studies with large sample size are needed to further assess the associations. |
| first_indexed | 2024-03-08T10:14:05Z |
| format | Article |
| id | doaj.art-dcc6375810b74831ac886d6d2588c52c |
| institution | Directory Open Access Journal |
| issn | 2538-4635 |
| language | English |
| last_indexed | 2024-03-08T10:14:05Z |
| publishDate | 2016-12-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Biology |
| spelling | doaj.art-dcc6375810b74831ac886d6d2588c52c2024-01-29T05:43:49ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Biology2538-46352016-12-0114899510.31557/apjcb.2016.1.4.89-95205Association between TP53 codon 72 G>C Polymorphism and Thyroid Carcinoma Risk: An Up-to-Date Meta-AnalysisJamal Jafari Nedooshan0Mohammad Forat YazdiHossein Neamatzadeh1Masoud Zare Shehneh2Saeed Kargar3Niloofar Seddighi4Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of Medical Genetics, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Objective: Many published data on the association between p53 codon 72 G>C polymorphism and thyroid carcinoma risk showed inconclusive results. The aim this study was to assess the association between p53 codon 72 G>C polymorphism and thyroid cancer risk. Methods: A literature search of PubMed, EMBASE, Google scholar and Web of Science databases for case–control studies examining the association between p53 codon 72 G>C polymorphism and thyroid cancer susceptibility up October 2016 was performed. Odds ratios (OR) with 95 % confidence intervals (95 % CI) were used to assess the strength of the association. Results: A total of 12 case–control studies involving 2,062 thyroid cancer patients and 3,027 controls were included. There was a significant association between the p53 codon 72 G>C polymorphism and thyroid cancer susceptibility in the overall populations under homozygote (CC vs. GG: OR = 1.18, 95% CI 1.12-3.05, P = 0.01) and recessive model (CC vs. GC+GG: OR = 1.73, 95% CI 1.16-2.59, P = 0.007). Subgroup analysis by ethnicity showed that there was no significant association between p53 codon 72 G>C polymorphism and thyroid cancer risk in Caucasians, Asians and mixed Brazilian. No significant publication bias was observed by using Begg’s funnel plot and Egger’s test. Conclusion: Present meta-analysis indicated that the p53 codon 72 G>C polymorphism may be associated with thyroid cancer risk. However, more studies with large sample size are needed to further assess the associations.http://www.waocp.com/journal/index.php/apjcb/article/view/205thyroid cancer- p53- codon 72- polymorphism- meta-analysis |
| spellingShingle | Jamal Jafari Nedooshan Mohammad Forat Yazdi Hossein Neamatzadeh Masoud Zare Shehneh Saeed Kargar Niloofar Seddighi Association between TP53 codon 72 G>C Polymorphism and Thyroid Carcinoma Risk: An Up-to-Date Meta-Analysis Asian Pacific Journal of Cancer Biology thyroid cancer- p53- codon 72- polymorphism- meta-analysis |
| title | Association between TP53 codon 72 G>C Polymorphism and Thyroid Carcinoma Risk: An Up-to-Date Meta-Analysis |
| title_full | Association between TP53 codon 72 G>C Polymorphism and Thyroid Carcinoma Risk: An Up-to-Date Meta-Analysis |
| title_fullStr | Association between TP53 codon 72 G>C Polymorphism and Thyroid Carcinoma Risk: An Up-to-Date Meta-Analysis |
| title_full_unstemmed | Association between TP53 codon 72 G>C Polymorphism and Thyroid Carcinoma Risk: An Up-to-Date Meta-Analysis |
| title_short | Association between TP53 codon 72 G>C Polymorphism and Thyroid Carcinoma Risk: An Up-to-Date Meta-Analysis |
| title_sort | association between tp53 codon 72 g c polymorphism and thyroid carcinoma risk an up to date meta analysis |
| topic | thyroid cancer- p53- codon 72- polymorphism- meta-analysis |
| url | http://www.waocp.com/journal/index.php/apjcb/article/view/205 |
| work_keys_str_mv | AT jamaljafarinedooshan associationbetweentp53codon72gcpolymorphismandthyroidcarcinomariskanuptodatemetaanalysis AT mohammadforatyazdi associationbetweentp53codon72gcpolymorphismandthyroidcarcinomariskanuptodatemetaanalysis AT hosseinneamatzadeh associationbetweentp53codon72gcpolymorphismandthyroidcarcinomariskanuptodatemetaanalysis AT masoudzareshehneh associationbetweentp53codon72gcpolymorphismandthyroidcarcinomariskanuptodatemetaanalysis AT saeedkargar associationbetweentp53codon72gcpolymorphismandthyroidcarcinomariskanuptodatemetaanalysis AT niloofarseddighi associationbetweentp53codon72gcpolymorphismandthyroidcarcinomariskanuptodatemetaanalysis |