Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm–Associated Regions to Potential Candidate Genes

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm–Associated Regions to Potential Candidate Genes

Background We previously showed that intracranial aneurysm (IA)–associated single‐nucleotide polymorphisms are enriched in promoters and putative enhancers identified in the human circle of Willis, on which IAs develop, suggesting a role for promoters and enhancers in IAs. We further investigated th...

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Bibliographic Details
Main Authors: Melanie D. Laarman, Geert Geeven, Phil Barnett, Gabriël J. E. Rinkel, Wouter de Laat, Ynte M. Ruigrok, Jeroen Bakkers
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
circle of Willis
gene regulation
intracranial aneurysm
single‐nucleotide polymorphism
zebrafish
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.011201

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