Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts.

Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts.

Interstrand crosslink (ICL)-inducing agents block the separation of the two DNA strands. They prevent transcription and replication and are used in clinics for the treatment of cancer and skin diseases. Here, we have introduced a single psoralen ICL at a specific site in plasmid DNA using a triplex-...

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Bibliographic Details
Main Authors: Cyrille Le Breton, Magali Hennion, Paola B Arimondo, Olivier Hyrien
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3078125?pdf=render

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