ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study
<p>Abstract</p> <p>Background</p> <p>A disintegrin and metalloproteinase (ADAMs) have been associated with multiple malignancies. ADAMs are involved in cell fusion, cell migration, membrane protein shedding and proteolysis. ADAM8 has been found to be overexpressed in sq...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-02-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2407/12/76 |
| _version_ | 1819182608963076096 |
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| author | Zielinski Valerie Brunner Markus Heiduschka Gregor Schneider Sven Seemann Rudolf Erovic Boban Thurnher Dietmar |
| author_facet | Zielinski Valerie Brunner Markus Heiduschka Gregor Schneider Sven Seemann Rudolf Erovic Boban Thurnher Dietmar |
| author_sort | Zielinski Valerie |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>A disintegrin and metalloproteinase (ADAMs) have been associated with multiple malignancies. ADAMs are involved in cell fusion, cell migration, membrane protein shedding and proteolysis. ADAM8 has been found to be overexpressed in squamous cell carcinomas of the lung. A new study showed that ADAM8 is significantly overexpressed in metastasis of squamous cell carcinomas of the head and neck (HNSCC).</p> <p>Methods</p> <p>We determined ADAM8 levels in the serum of 79 HNSCC patients at the time of diagnosis, in 35 patients 3 months after treatment and in 10 patients 1 year after therapy and compared the results to the sera of 31 healthy volunteers. We also constructed tissue microarrays to detect ADAM8 immunohistochemically in 100 patients. The results were correlated with the survival data of the patients to determine the diagnostic and prognostic value.</p> <p>Results</p> <p>The data demonstrated that patients with high ADAM8 expression in the tumor have worse survival rates. We found that high ADAM8 serum levels correlated with high ADAM8 expression in tumor samples. Soluble ADAM8 levels did not show any prognostic or diagnostic properties.</p> <p>Conclusion</p> <p>In summary ADAM8 expression is a prognostic factor for survival of patients with head and neck squamous cell carcinoma.</p> |
| first_indexed | 2024-12-22T22:48:51Z |
| format | Article |
| id | doaj.art-dcc85e39de2f47d1b9d63c50dee38111 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-22T22:48:51Z |
| publishDate | 2012-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-dcc85e39de2f47d1b9d63c50dee381112022-12-21T18:10:01ZengBMCBMC Cancer1471-24072012-02-011217610.1186/1471-2407-12-76ADAM8 in squamous cell carcinoma of the head and neck: a retrospective studyZielinski ValerieBrunner MarkusHeiduschka GregorSchneider SvenSeemann RudolfErovic BobanThurnher Dietmar<p>Abstract</p> <p>Background</p> <p>A disintegrin and metalloproteinase (ADAMs) have been associated with multiple malignancies. ADAMs are involved in cell fusion, cell migration, membrane protein shedding and proteolysis. ADAM8 has been found to be overexpressed in squamous cell carcinomas of the lung. A new study showed that ADAM8 is significantly overexpressed in metastasis of squamous cell carcinomas of the head and neck (HNSCC).</p> <p>Methods</p> <p>We determined ADAM8 levels in the serum of 79 HNSCC patients at the time of diagnosis, in 35 patients 3 months after treatment and in 10 patients 1 year after therapy and compared the results to the sera of 31 healthy volunteers. We also constructed tissue microarrays to detect ADAM8 immunohistochemically in 100 patients. The results were correlated with the survival data of the patients to determine the diagnostic and prognostic value.</p> <p>Results</p> <p>The data demonstrated that patients with high ADAM8 expression in the tumor have worse survival rates. We found that high ADAM8 serum levels correlated with high ADAM8 expression in tumor samples. Soluble ADAM8 levels did not show any prognostic or diagnostic properties.</p> <p>Conclusion</p> <p>In summary ADAM8 expression is a prognostic factor for survival of patients with head and neck squamous cell carcinoma.</p>http://www.biomedcentral.com/1471-2407/12/76ADAM8Squamous cell carcinomaHead and neck |
| spellingShingle | Zielinski Valerie Brunner Markus Heiduschka Gregor Schneider Sven Seemann Rudolf Erovic Boban Thurnher Dietmar ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study BMC Cancer ADAM8 Squamous cell carcinoma Head and neck |
| title | ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study |
| title_full | ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study |
| title_fullStr | ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study |
| title_full_unstemmed | ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study |
| title_short | ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study |
| title_sort | adam8 in squamous cell carcinoma of the head and neck a retrospective study |
| topic | ADAM8 Squamous cell carcinoma Head and neck |
| url | http://www.biomedcentral.com/1471-2407/12/76 |
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