Improving 2-Chlorotrityl Chloride (2-CTC) Resin Activation

Improving 2-Chlorotrityl Chloride (2-CTC) Resin Activation

Used in solid-phase peptide synthesis (SPPS) for peptides with an acid termination, the 2-chlorotrityl chloride (2-CTC) resin is highly susceptible to moisture, leading to reduced resin loading and lower synthetic yields. It is therefore recommended that the resin be activated with thionyl chloride...

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Bibliographic Details
Main Authors: Tanya Román, Gerardo Acosta, Beatriz G. de la Torre, Constanza Cárdenas, Fanny Guzmán, Fernando Albericio
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Methods and Protocols
Subjects:
2-CTC resin activation
2-CTC resin reutilization
resin loading
solid-phase peptide synthesis
Online Access:https://www.mdpi.com/2409-9279/6/5/82

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