Orthologs of human circulating miRNAs associated with hepatocellular carcinoma are elevated in mouse plasma months before tumour detection

Abstract Research examining the potential for circulating miRNA to serve as markers for preneoplastic lesions or early-stage hepatocellular carcinoma (HCC) is hindered by the difficulties of obtaining samples from asymptomatic individuals. As a surrogate for human samples, we identified hub miRNAs i...

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Bibliographic Details
Main Authors: Liang-Hao Ding, Christina M. Fallgren, Yongjia Yu, Maureen McCarthy, Elijah F. Edmondson, Robert L. Ullrich, Michael. M. Weil, Michael D. Story
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15061-5