The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysis
Summary: Background: Contemporary data for the global burden of sore throat and group A Streptococcus (Strep A) pharyngitis are required to understand the frequency of disease and develop value propositions for Strep A vaccines. Methods: We used Clarivate Analytics’ Web of Science platform to searc...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537022001882 |
| _version_ | 1811238539604525056 |
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| author | Kate M. Miller Jonathan R. Carapetis Chris A. Van Beneden Daniel Cadarette Jessica N. Daw Hannah C. Moore David E. Bloom Jeffrey W. Cannon |
| author_facet | Kate M. Miller Jonathan R. Carapetis Chris A. Van Beneden Daniel Cadarette Jessica N. Daw Hannah C. Moore David E. Bloom Jeffrey W. Cannon |
| author_sort | Kate M. Miller |
| collection | DOAJ |
| description | Summary: Background: Contemporary data for the global burden of sore throat and group A Streptococcus (Strep A) pharyngitis are required to understand the frequency of disease and develop value propositions for Strep A vaccines. Methods: We used Clarivate Analytics’ Web of Science platform to search WoS core collection, PubMed, Medline, data citation index, KCI-Korean Journal Database, Russian Science Citation Index, and the SciELO Citation Index for articles published between Jan 1, 2000, and Feb 15, 2021, from any country and in any language. The risk of bias was assessed using the JBI critical appraisal checklist. We used random-effects meta-analyses to pool sore throat and Strep A sore throat incidence rates from community-based studies. Our study was registered with PROSPERO (CRD42020181103). Findings: Of 5,529 articles identified by the search strategy, 26 studies met the inclusion criteria, but only two included data to determine incidence among adults. The pooled incidence rate, calculated for children only, was 82.2 episodes per 100 child-years (95% CI 25.2–286.3, I2 = 100%) for sore throat (7 studies; 7,964 person years) and 22.1 episodes per 100 child-years (95% CI 14.7–33.1, I2 = 98%) for Strep A sore throat (9 studies; 15,696 person years). The pooled cumulative incidence rate of sore throat from five studies was 31.9 per 100 children. There was significant methodological and statistical heterogeneity among studies, and five of 26 studies had a risk of bias score less than five (range: nine [maximum score] to one). Interpretation: Strep A sore throat has a considerable global burden. However, methodologically standardised studies are required to quantify that burden, analyse differences in rates between populations, and evaluate the likely impact of future Strep A vaccines. Funding: This study was funded by Wellcome Trust 215,490/Z/19/Z. |
| first_indexed | 2024-04-12T12:43:57Z |
| format | Article |
| id | doaj.art-dccc2d1502af421b8808ccbb7ab35024 |
| institution | Directory Open Access Journal |
| issn | 2589-5370 |
| language | English |
| last_indexed | 2024-04-12T12:43:57Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj.art-dccc2d1502af421b8808ccbb7ab350242022-12-22T03:32:41ZengElsevierEClinicalMedicine2589-53702022-06-0148101458The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysisKate M. Miller0Jonathan R. Carapetis1Chris A. Van Beneden2Daniel Cadarette3Jessica N. Daw4Hannah C. Moore5David E. Bloom6Jeffrey W. Cannon7Wesfarmers Centre of Vaccines and Telethon Kids Institute, University of Western Australia, PO Box 855, West Perth, Nedlands, WA 6872, Australia; Corresponding author.Wesfarmers Centre of Vaccines and Telethon Kids Institute, University of Western Australia, PO Box 855, West Perth, Nedlands, WA 6872, Australia; Perth Children's Hospital, Nedlands, WA, AustraliaCDC Foundation, Atlanta, GA, USADepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USAWesfarmers Centre of Vaccines and Telethon Kids Institute, University of Western Australia, PO Box 855, West Perth, Nedlands, WA 6872, AustraliaWesfarmers Centre of Vaccines and Telethon Kids Institute, University of Western Australia, PO Box 855, West Perth, Nedlands, WA 6872, AustraliaDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USAWesfarmers Centre of Vaccines and Telethon Kids Institute, University of Western Australia, PO Box 855, West Perth, Nedlands, WA 6872, Australia; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USASummary: Background: Contemporary data for the global burden of sore throat and group A Streptococcus (Strep A) pharyngitis are required to understand the frequency of disease and develop value propositions for Strep A vaccines. Methods: We used Clarivate Analytics’ Web of Science platform to search WoS core collection, PubMed, Medline, data citation index, KCI-Korean Journal Database, Russian Science Citation Index, and the SciELO Citation Index for articles published between Jan 1, 2000, and Feb 15, 2021, from any country and in any language. The risk of bias was assessed using the JBI critical appraisal checklist. We used random-effects meta-analyses to pool sore throat and Strep A sore throat incidence rates from community-based studies. Our study was registered with PROSPERO (CRD42020181103). Findings: Of 5,529 articles identified by the search strategy, 26 studies met the inclusion criteria, but only two included data to determine incidence among adults. The pooled incidence rate, calculated for children only, was 82.2 episodes per 100 child-years (95% CI 25.2–286.3, I2 = 100%) for sore throat (7 studies; 7,964 person years) and 22.1 episodes per 100 child-years (95% CI 14.7–33.1, I2 = 98%) for Strep A sore throat (9 studies; 15,696 person years). The pooled cumulative incidence rate of sore throat from five studies was 31.9 per 100 children. There was significant methodological and statistical heterogeneity among studies, and five of 26 studies had a risk of bias score less than five (range: nine [maximum score] to one). Interpretation: Strep A sore throat has a considerable global burden. However, methodologically standardised studies are required to quantify that burden, analyse differences in rates between populations, and evaluate the likely impact of future Strep A vaccines. Funding: This study was funded by Wellcome Trust 215,490/Z/19/Z.http://www.sciencedirect.com/science/article/pii/S2589537022001882PharyngitisSore throatStreptococcusIncidenceSurveillanceBurden |
| spellingShingle | Kate M. Miller Jonathan R. Carapetis Chris A. Van Beneden Daniel Cadarette Jessica N. Daw Hannah C. Moore David E. Bloom Jeffrey W. Cannon The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysis EClinicalMedicine Pharyngitis Sore throat Streptococcus Incidence Surveillance Burden |
| title | The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysis |
| title_full | The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysis |
| title_fullStr | The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysis |
| title_full_unstemmed | The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysis |
| title_short | The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysis |
| title_sort | global burden of sore throat and group a streptococcus pharyngitis a systematic review and meta analysis |
| topic | Pharyngitis Sore throat Streptococcus Incidence Surveillance Burden |
| url | http://www.sciencedirect.com/science/article/pii/S2589537022001882 |
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