HIV-2 mediated effects on target and bystander cells induce plasma proteome remodeling
Summary: Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate th...
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| 格式: | 文件 |
| 语言: | English |
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Elsevier
2024-04-01
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| 丛编: | iScience |
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| 在线阅读: | http://www.sciencedirect.com/science/article/pii/S2589004224005650 |
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| author | Emil Johansson Jamirah Nazziwa Eva Freyhult Mun-Gwan Hong Jacob Lindman Malin Neptin Sara Karlson Melinda Rezeli Antonio J. Biague Patrik Medstrand Fredrik Månsson Hans Norrgren Joakim Esbjörnsson Marianne Jansson |
| author_facet | Emil Johansson Jamirah Nazziwa Eva Freyhult Mun-Gwan Hong Jacob Lindman Malin Neptin Sara Karlson Melinda Rezeli Antonio J. Biague Patrik Medstrand Fredrik Månsson Hans Norrgren Joakim Esbjörnsson Marianne Jansson |
| author_sort | Emil Johansson |
| collection | DOAJ |
| description | Summary: Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate the impact of viremic and aviremic HIV-2 infection on target and bystander cell pathology, we used data-independent acquisition mass spectrometry to determine plasma signatures of tissue and cell type engagement. Proteins derived from target and bystander cells in multiple tissues, such as the gastrointestinal tract and brain, were detected at elevated levels in plasma of PLWH2, compared with HIV negative controls. Moreover, viremic HIV-2 infection appeared to induce enhanced release of proteins from a broader range of tissues compared to aviremic HIV-2 infection. This study expands the knowledge on the link between plasma proteome remodeling and the pathological cell engagement in tissues during HIV-2 infection. |
| first_indexed | 2024-04-25T00:16:07Z |
| format | Article |
| id | doaj.art-dccf8ab6ac1a42fd879b9b00b706cf0e |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-25T00:16:07Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-dccf8ab6ac1a42fd879b9b00b706cf0e2024-03-13T04:46:17ZengElsevieriScience2589-00422024-04-01274109344HIV-2 mediated effects on target and bystander cells induce plasma proteome remodelingEmil Johansson0Jamirah Nazziwa1Eva Freyhult2Mun-Gwan Hong3Jacob Lindman4Malin Neptin5Sara Karlson6Melinda Rezeli7Antonio J. Biague8Patrik Medstrand9Fredrik Månsson10Hans Norrgren11Joakim Esbjörnsson12Marianne Jansson13Department of Translational Medicine, Lund University, Lund, Sweden; Lund University Virus Centre, Lund, SwedenDepartment of Translational Medicine, Lund University, Lund, Sweden; Lund University Virus Centre, Lund, SwedenDepartment of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, SwedenNational Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SwedenDepartment of Clinical Sciences Lund, Lund University, Lund, SwedenDepartment of Translational Medicine, Lund University, Lund, Sweden; Lund University Virus Centre, Lund, SwedenLund University Virus Centre, Lund, Sweden; Department of Laboratory Medicine, Lund University, Lund, SwedenBioMS – Swedish National Infrastructure for Biological Mass Spectrometry, Lund University, Lund, SwedenNational Public Health Laboratory, Bissau, Guinea-BissauDepartment of Translational Medicine, Lund University, Lund, Sweden; Lund University Virus Centre, Lund, SwedenDepartment of Translational Medicine, Lund University, Lund, SwedenDepartment of Clinical Sciences Lund, Lund University, Lund, SwedenDepartment of Translational Medicine, Lund University, Lund, Sweden; Lund University Virus Centre, Lund, Sweden; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Corresponding authorLund University Virus Centre, Lund, Sweden; Department of Laboratory Medicine, Lund University, Lund, Sweden; Corresponding authorSummary: Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate the impact of viremic and aviremic HIV-2 infection on target and bystander cell pathology, we used data-independent acquisition mass spectrometry to determine plasma signatures of tissue and cell type engagement. Proteins derived from target and bystander cells in multiple tissues, such as the gastrointestinal tract and brain, were detected at elevated levels in plasma of PLWH2, compared with HIV negative controls. Moreover, viremic HIV-2 infection appeared to induce enhanced release of proteins from a broader range of tissues compared to aviremic HIV-2 infection. This study expands the knowledge on the link between plasma proteome remodeling and the pathological cell engagement in tissues during HIV-2 infection.http://www.sciencedirect.com/science/article/pii/S2589004224005650DiseaseHuman specimenProteomicsVirology |
| spellingShingle | Emil Johansson Jamirah Nazziwa Eva Freyhult Mun-Gwan Hong Jacob Lindman Malin Neptin Sara Karlson Melinda Rezeli Antonio J. Biague Patrik Medstrand Fredrik Månsson Hans Norrgren Joakim Esbjörnsson Marianne Jansson HIV-2 mediated effects on target and bystander cells induce plasma proteome remodeling iScience Disease Human specimen Proteomics Virology |
| title | HIV-2 mediated effects on target and bystander cells induce plasma proteome remodeling |
| title_full | HIV-2 mediated effects on target and bystander cells induce plasma proteome remodeling |
| title_fullStr | HIV-2 mediated effects on target and bystander cells induce plasma proteome remodeling |
| title_full_unstemmed | HIV-2 mediated effects on target and bystander cells induce plasma proteome remodeling |
| title_short | HIV-2 mediated effects on target and bystander cells induce plasma proteome remodeling |
| title_sort | hiv 2 mediated effects on target and bystander cells induce plasma proteome remodeling |
| topic | Disease Human specimen Proteomics Virology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224005650 |
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