Intravenous Immunoglobulin Treatment in Kawasaki Disease Decreases the Incidence of Myopia
Kawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5 years old. The most significant complication is coronary artery lesions, but several ocular manifestations have also been reported. Recently, one study revealed an increasing incidence of myopia among K...
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/7/1381 |
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| author | Hun-Ju Yu Meng-Ni Chuang Chiao-Lun Chu Pei-Lin Wu Shu-Chen Ho Ho-Chang Kuo |
| author_facet | Hun-Ju Yu Meng-Ni Chuang Chiao-Lun Chu Pei-Lin Wu Shu-Chen Ho Ho-Chang Kuo |
| author_sort | Hun-Ju Yu |
| collection | DOAJ |
| description | Kawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5 years old. The most significant complication is coronary artery lesions, but several ocular manifestations have also been reported. Recently, one study revealed an increasing incidence of myopia among KD patients. Therefore, the aim of this study was to assess the difference in myopic incidence between Kawasaki disease (KD) patients treated with aspirin and intravenous immunoglobulin (IVIG). <i>Materials and methods:</i> We carried out a nationwide retrospective cohort study by analyzing the data of KD patients (ICD-9-CM code 4461) from Taiwan’s National Health Insurance Research Database (NHIRD) during the period of 1996–2013. <i>Results:</i> A total of 14,102 diagnosed KD were found in Taiwan during the study period. After excluded missing data, treatment strategy and age distribution, a total of 1446 KD patients were enrolled for analysis including 53 of which received aspirin (without IVIG) and 1393 of which were treated with IVIG. Patients who had myopia, astigmatism, glaucoma, cataract, etc. prior to their KD diagnosis were excluded. The age range was 0 to 6 years old. According to the cumulative curves, our results demonstrated that the myopic incidence in the IVIG group was significantly lower than the aspirin group (hazard ratio: 0.59, 95% confidence intervals: 0.36~0.96, <i>p</i> = 0.02). Treatment with IVIG for KD patients may have benefit for myopia control. <i>Conclusion:</i> Compared to aspirin, IVIG may decrease the myopic risk in KD patients. However, it needs further investigation including clinical vision survey of myopia due to the limitations of this population-based study. |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-dcd1aa8a856f4206ac72f3d05b69affd2023-11-21T13:20:32ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01107138110.3390/jcm10071381Intravenous Immunoglobulin Treatment in Kawasaki Disease Decreases the Incidence of MyopiaHun-Ju Yu0Meng-Ni Chuang1Chiao-Lun Chu2Pei-Lin Wu3Shu-Chen Ho4Ho-Chang Kuo5Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 83301, TaiwanDepartment of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 83301, TaiwanKawasaki Disease Center and Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 83301, TaiwanKawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5 years old. The most significant complication is coronary artery lesions, but several ocular manifestations have also been reported. Recently, one study revealed an increasing incidence of myopia among KD patients. Therefore, the aim of this study was to assess the difference in myopic incidence between Kawasaki disease (KD) patients treated with aspirin and intravenous immunoglobulin (IVIG). <i>Materials and methods:</i> We carried out a nationwide retrospective cohort study by analyzing the data of KD patients (ICD-9-CM code 4461) from Taiwan’s National Health Insurance Research Database (NHIRD) during the period of 1996–2013. <i>Results:</i> A total of 14,102 diagnosed KD were found in Taiwan during the study period. After excluded missing data, treatment strategy and age distribution, a total of 1446 KD patients were enrolled for analysis including 53 of which received aspirin (without IVIG) and 1393 of which were treated with IVIG. Patients who had myopia, astigmatism, glaucoma, cataract, etc. prior to their KD diagnosis were excluded. The age range was 0 to 6 years old. According to the cumulative curves, our results demonstrated that the myopic incidence in the IVIG group was significantly lower than the aspirin group (hazard ratio: 0.59, 95% confidence intervals: 0.36~0.96, <i>p</i> = 0.02). Treatment with IVIG for KD patients may have benefit for myopia control. <i>Conclusion:</i> Compared to aspirin, IVIG may decrease the myopic risk in KD patients. However, it needs further investigation including clinical vision survey of myopia due to the limitations of this population-based study.https://www.mdpi.com/2077-0383/10/7/1381myopiaKawasaki diseaseintravenous immunoglobulin |
| spellingShingle | Hun-Ju Yu Meng-Ni Chuang Chiao-Lun Chu Pei-Lin Wu Shu-Chen Ho Ho-Chang Kuo Intravenous Immunoglobulin Treatment in Kawasaki Disease Decreases the Incidence of Myopia Journal of Clinical Medicine myopia Kawasaki disease intravenous immunoglobulin |
| title | Intravenous Immunoglobulin Treatment in Kawasaki Disease Decreases the Incidence of Myopia |
| title_full | Intravenous Immunoglobulin Treatment in Kawasaki Disease Decreases the Incidence of Myopia |
| title_fullStr | Intravenous Immunoglobulin Treatment in Kawasaki Disease Decreases the Incidence of Myopia |
| title_full_unstemmed | Intravenous Immunoglobulin Treatment in Kawasaki Disease Decreases the Incidence of Myopia |
| title_short | Intravenous Immunoglobulin Treatment in Kawasaki Disease Decreases the Incidence of Myopia |
| title_sort | intravenous immunoglobulin treatment in kawasaki disease decreases the incidence of myopia |
| topic | myopia Kawasaki disease intravenous immunoglobulin |
| url | https://www.mdpi.com/2077-0383/10/7/1381 |
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