PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways

PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways

Abstract Background PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in cell proliferation and tumorigenesis. However, the precise mechanism of action of PCNP in the process of tumor growth has not yet been fully elucidated. Methods ShRNA knockdown and overexpression of P...

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Bibliographic Details
Main Authors: Dong-Dong Wu, Ying-Ran Gao, Tao Li, Da-Yong Wang, Dan Lu, Shi-Yu Liu, Ya Hong, Hui-Bin Ning, Jun-Ping Liu, Jia Shang, Jun-Feng Shi, Jian-She Wei, Xin-Ying Ji
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Cancer
Subjects:
PEST-containing nuclear protein
Neuroblastoma
Angiogenesis
Apoptosis
Signaling pathway
Online Access:http://link.springer.com/article/10.1186/s12885-018-4391-9

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