The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia
Preeclampsia (PE) is a disorder of pregnancy typically characterized by new onset hypertension after gestational week 20 and proteinuria. Although PE is one of the leading causes of maternal and perinatal morbidity and death worldwide, the mechanisms of the pathogenesis of the disease remain unclear...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/18/3/522 |
| _version_ | 1811334162159763456 |
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| author | Bhavisha Bakrania Jeremy Duncan Junie P. Warrington Joey P. Granger |
| author_facet | Bhavisha Bakrania Jeremy Duncan Junie P. Warrington Joey P. Granger |
| author_sort | Bhavisha Bakrania |
| collection | DOAJ |
| description | Preeclampsia (PE) is a disorder of pregnancy typically characterized by new onset hypertension after gestational week 20 and proteinuria. Although PE is one of the leading causes of maternal and perinatal morbidity and death worldwide, the mechanisms of the pathogenesis of the disease remain unclear and treatment options are limited. However, there is increasing evidence to suggest that endothelin-1 (ET-1) plays a critical role in the pathophysiology of PE. Multiple studies report that ET-1 is increased in PE and some studies report a positive correlation between ET-1 and the severity of symptoms. A number of experimental models of PE are also associated with elevated tissue levels of prepro ET-1 mRNA. Moreover, experimental models of PE (placental ischemia, sFlt-1 infusion, Tumor necrosis factor (TNF) -α infusion, and Angiotensin II type 1 receptor autoantibody (AT1-AA) infusion) have proven to be susceptible to Endothelin Type A (ETA) receptor antagonism. While the results are promising, further work is needed to determine whether ET antagonists could provide an effective therapy for the management of preeclampsia. |
| first_indexed | 2024-04-13T17:03:44Z |
| format | Article |
| id | doaj.art-dcd483e993dc485bb5eeba9577a11aa8 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T17:03:44Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dcd483e993dc485bb5eeba9577a11aa82022-12-22T02:38:34ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-02-0118352210.3390/ijms18030522ijms18030522The Endothelin Type A Receptor as a Potential Therapeutic Target in PreeclampsiaBhavisha Bakrania0Jeremy Duncan1Junie P. Warrington2Joey P. Granger3Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USAPreeclampsia (PE) is a disorder of pregnancy typically characterized by new onset hypertension after gestational week 20 and proteinuria. Although PE is one of the leading causes of maternal and perinatal morbidity and death worldwide, the mechanisms of the pathogenesis of the disease remain unclear and treatment options are limited. However, there is increasing evidence to suggest that endothelin-1 (ET-1) plays a critical role in the pathophysiology of PE. Multiple studies report that ET-1 is increased in PE and some studies report a positive correlation between ET-1 and the severity of symptoms. A number of experimental models of PE are also associated with elevated tissue levels of prepro ET-1 mRNA. Moreover, experimental models of PE (placental ischemia, sFlt-1 infusion, Tumor necrosis factor (TNF) -α infusion, and Angiotensin II type 1 receptor autoantibody (AT1-AA) infusion) have proven to be susceptible to Endothelin Type A (ETA) receptor antagonism. While the results are promising, further work is needed to determine whether ET antagonists could provide an effective therapy for the management of preeclampsia.http://www.mdpi.com/1422-0067/18/3/522preeclampsiapregnancyhypertensionendothelinendotheliumplacentacardiovascularblood pressurevascular smooth muscle |
| spellingShingle | Bhavisha Bakrania Jeremy Duncan Junie P. Warrington Joey P. Granger The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia International Journal of Molecular Sciences preeclampsia pregnancy hypertension endothelin endothelium placenta cardiovascular blood pressure vascular smooth muscle |
| title | The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia |
| title_full | The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia |
| title_fullStr | The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia |
| title_full_unstemmed | The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia |
| title_short | The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia |
| title_sort | endothelin type a receptor as a potential therapeutic target in preeclampsia |
| topic | preeclampsia pregnancy hypertension endothelin endothelium placenta cardiovascular blood pressure vascular smooth muscle |
| url | http://www.mdpi.com/1422-0067/18/3/522 |
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