Delivery of Growth Factors to Enhance Bone Repair
The management of critical-sized bone defects caused by nonunion, trauma, infection, malignancy, pseudoarthrosis, and osteolysis poses complex reconstruction challenges for orthopedic surgeons. Current treatment modalities, including autograft, allograft, and distraction osteogenesis, are insufficie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/10/11/1252 |
| _version_ | 1827640536091066368 |
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| author | Jacob R. Ball Tara Shelby Fergui Hernandez Cory K. Mayfield Jay R. Lieberman |
| author_facet | Jacob R. Ball Tara Shelby Fergui Hernandez Cory K. Mayfield Jay R. Lieberman |
| author_sort | Jacob R. Ball |
| collection | DOAJ |
| description | The management of critical-sized bone defects caused by nonunion, trauma, infection, malignancy, pseudoarthrosis, and osteolysis poses complex reconstruction challenges for orthopedic surgeons. Current treatment modalities, including autograft, allograft, and distraction osteogenesis, are insufficient for the diverse range of pathology encountered in clinical practice, with significant complications associated with each. Therefore, there is significant interest in the development of delivery vehicles for growth factors to aid in bone repair in these settings. This article reviews innovative strategies for the management of critical-sized bone loss, including novel scaffolds designed for controlled release of rhBMP, bioengineered extracellular vesicles for delivery of intracellular signaling molecules, and advances in regional gene therapy for sustained signaling strategies. Improvement in the delivery of growth factors to areas of significant bone loss has the potential to revolutionize current treatment for this complex clinical challenge. |
| first_indexed | 2024-03-09T17:02:00Z |
| format | Article |
| id | doaj.art-dcd52ad1d5324a499244c10a5179846c |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T17:02:00Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-dcd52ad1d5324a499244c10a5179846c2023-11-24T14:29:40ZengMDPI AGBioengineering2306-53542023-10-011011125210.3390/bioengineering10111252Delivery of Growth Factors to Enhance Bone RepairJacob R. Ball0Tara Shelby1Fergui Hernandez2Cory K. Mayfield3Jay R. Lieberman4Department of Orthopaedic Surgery, University of Southern California Keck School of Medicine, 1500 San Pablo St., Los Angeles, CA 90033, USADepartment of Orthopaedic Surgery, University of Southern California Keck School of Medicine, 1500 San Pablo St., Los Angeles, CA 90033, USADepartment of Orthopaedic Surgery, University of Southern California Keck School of Medicine, 1500 San Pablo St., Los Angeles, CA 90033, USADepartment of Orthopaedic Surgery, University of Southern California Keck School of Medicine, 1500 San Pablo St., Los Angeles, CA 90033, USADepartment of Orthopaedic Surgery, University of Southern California Keck School of Medicine, 1500 San Pablo St., Los Angeles, CA 90033, USAThe management of critical-sized bone defects caused by nonunion, trauma, infection, malignancy, pseudoarthrosis, and osteolysis poses complex reconstruction challenges for orthopedic surgeons. Current treatment modalities, including autograft, allograft, and distraction osteogenesis, are insufficient for the diverse range of pathology encountered in clinical practice, with significant complications associated with each. Therefore, there is significant interest in the development of delivery vehicles for growth factors to aid in bone repair in these settings. This article reviews innovative strategies for the management of critical-sized bone loss, including novel scaffolds designed for controlled release of rhBMP, bioengineered extracellular vesicles for delivery of intracellular signaling molecules, and advances in regional gene therapy for sustained signaling strategies. Improvement in the delivery of growth factors to areas of significant bone loss has the potential to revolutionize current treatment for this complex clinical challenge.https://www.mdpi.com/2306-5354/10/11/1252stem cellgene therapycritical-sized defectgrowth factorBMP |
| spellingShingle | Jacob R. Ball Tara Shelby Fergui Hernandez Cory K. Mayfield Jay R. Lieberman Delivery of Growth Factors to Enhance Bone Repair Bioengineering stem cell gene therapy critical-sized defect growth factor BMP |
| title | Delivery of Growth Factors to Enhance Bone Repair |
| title_full | Delivery of Growth Factors to Enhance Bone Repair |
| title_fullStr | Delivery of Growth Factors to Enhance Bone Repair |
| title_full_unstemmed | Delivery of Growth Factors to Enhance Bone Repair |
| title_short | Delivery of Growth Factors to Enhance Bone Repair |
| title_sort | delivery of growth factors to enhance bone repair |
| topic | stem cell gene therapy critical-sized defect growth factor BMP |
| url | https://www.mdpi.com/2306-5354/10/11/1252 |
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