Prognostic Value of Ki-67 Index in Patients With Endometrial Stromal Sarcoma
ObjectiveThe Ki-67 index is used to evaluate cell proliferation activity, which is related to tumor progression, metastasis, and prognosis. We aimed to explore the prognostic value of Ki-67 index in endometrial stromal sarcoma and to explore the optimal cut-off value of Ki-67 index for predicting re...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.823505/full |
| _version_ | 1818954820577394688 |
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| author | Yu Meng Quan Quan Fenfen Zhang Yao Liu Siling Ren Xiaoling Mu |
| author_facet | Yu Meng Quan Quan Fenfen Zhang Yao Liu Siling Ren Xiaoling Mu |
| author_sort | Yu Meng |
| collection | DOAJ |
| description | ObjectiveThe Ki-67 index is used to evaluate cell proliferation activity, which is related to tumor progression, metastasis, and prognosis. We aimed to explore the prognostic value of Ki-67 index in endometrial stromal sarcoma and to explore the optimal cut-off value of Ki-67 index for predicting recurrent endometrial stromal sarcoma.MethodsA total of 82 patients with endometrial stromal sarcoma who were treated in our hospital were collected. Clinicopathological data of these patients were retrospectively analyzed. Ki-67 index was detected by the immunohistochemical method. Receiver operating characteristic curve and the Youden index were performed to determine the optimal cut-off value of Ki-67 index for predicting recurrent endometrial stromal sarcoma. The Cox regression was performed to analyze risk factors affecting prognosis of endometrial stromal sarcoma. The Kaplan–Meier method and Log-rank test were performed to analyze the survival of patients.ResultsThe optimal cut-off value of Ki-67 index for predicting recurrent endometrial stromal sarcoma was 35%. The results of univariate analysis showed that high Ki-67 index (≥35%) was statistically significantly bound up with shorter progress free survival and overall survival. The results of multivariate analysis showed that Ki-67 index (P = 0.001) and ovarian preservation (P = 0.040) were independent prognostic factors of progress free survival.ConclusionsA Ki-67 index cut-off of 35% was optimal for predicting recurrent endometrial stromal sarcoma. Ki-67 index may be a useful prognostic marker in endometrial stromal sarcoma. |
| first_indexed | 2024-12-20T10:28:15Z |
| format | Article |
| id | doaj.art-dcd72f678e94496ba6646a9dc85bfe40 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-20T10:28:15Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-dcd72f678e94496ba6646a9dc85bfe402022-12-21T19:43:47ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.823505823505Prognostic Value of Ki-67 Index in Patients With Endometrial Stromal SarcomaYu Meng0Quan Quan1Fenfen Zhang2Yao Liu3Siling Ren4Xiaoling Mu5Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Obstetrics and Gynecology, Chengdu First People Hospital, Chengdu, ChinaDepartment of Obstetrics, Chongqing Fuling District Maternal and Child Health Care, Chongqing, ChinaDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaObjectiveThe Ki-67 index is used to evaluate cell proliferation activity, which is related to tumor progression, metastasis, and prognosis. We aimed to explore the prognostic value of Ki-67 index in endometrial stromal sarcoma and to explore the optimal cut-off value of Ki-67 index for predicting recurrent endometrial stromal sarcoma.MethodsA total of 82 patients with endometrial stromal sarcoma who were treated in our hospital were collected. Clinicopathological data of these patients were retrospectively analyzed. Ki-67 index was detected by the immunohistochemical method. Receiver operating characteristic curve and the Youden index were performed to determine the optimal cut-off value of Ki-67 index for predicting recurrent endometrial stromal sarcoma. The Cox regression was performed to analyze risk factors affecting prognosis of endometrial stromal sarcoma. The Kaplan–Meier method and Log-rank test were performed to analyze the survival of patients.ResultsThe optimal cut-off value of Ki-67 index for predicting recurrent endometrial stromal sarcoma was 35%. The results of univariate analysis showed that high Ki-67 index (≥35%) was statistically significantly bound up with shorter progress free survival and overall survival. The results of multivariate analysis showed that Ki-67 index (P = 0.001) and ovarian preservation (P = 0.040) were independent prognostic factors of progress free survival.ConclusionsA Ki-67 index cut-off of 35% was optimal for predicting recurrent endometrial stromal sarcoma. Ki-67 index may be a useful prognostic marker in endometrial stromal sarcoma.https://www.frontiersin.org/articles/10.3389/fmed.2021.823505/fullendometrial stromal sarcomarecurrencepredictprognosisKi-67 |
| spellingShingle | Yu Meng Quan Quan Fenfen Zhang Yao Liu Siling Ren Xiaoling Mu Prognostic Value of Ki-67 Index in Patients With Endometrial Stromal Sarcoma Frontiers in Medicine endometrial stromal sarcoma recurrence predict prognosis Ki-67 |
| title | Prognostic Value of Ki-67 Index in Patients With Endometrial Stromal Sarcoma |
| title_full | Prognostic Value of Ki-67 Index in Patients With Endometrial Stromal Sarcoma |
| title_fullStr | Prognostic Value of Ki-67 Index in Patients With Endometrial Stromal Sarcoma |
| title_full_unstemmed | Prognostic Value of Ki-67 Index in Patients With Endometrial Stromal Sarcoma |
| title_short | Prognostic Value of Ki-67 Index in Patients With Endometrial Stromal Sarcoma |
| title_sort | prognostic value of ki 67 index in patients with endometrial stromal sarcoma |
| topic | endometrial stromal sarcoma recurrence predict prognosis Ki-67 |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.823505/full |
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