Effects of colloid pre-loading on thromboelastography during elective intracranial tumor surgery in pediatric patients: hydroxyethyl starch 130/0.4 versus 5% human albumin
Abstract Background Volume replacement therapy with colloid is still worth studying in major pediatric surgery with potential risk of bleeding. This study assessed the effects of 6% hydroxyethyl starch (HES) 130/0.4 and 5% Human Albumin (HA) on coagulation tested by thromboelastography (TEG) during...
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| Format: | Article |
| Language: | English |
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BMC
2017-04-01
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| Series: | BMC Anesthesiology |
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| Online Access: | http://link.springer.com/article/10.1186/s12871-017-0353-z |
| _version_ | 1811270516623802368 |
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| author | Yuanzhi Peng Jianer Du Xuan Zhao Xueyin Shi Yingwei Wang |
| author_facet | Yuanzhi Peng Jianer Du Xuan Zhao Xueyin Shi Yingwei Wang |
| author_sort | Yuanzhi Peng |
| collection | DOAJ |
| description | Abstract Background Volume replacement therapy with colloid is still worth studying in major pediatric surgery with potential risk of bleeding. This study assessed the effects of 6% hydroxyethyl starch (HES) 130/0.4 and 5% Human Albumin (HA) on coagulation tested by thromboelastography (TEG) during elective intracranial tumor surgery in pediatric patients. Methods In this randomized controlled trial, 60 patients undergoing intracranial tumor resection under general anesthesia were assigned to HES and HA groups (n = 30), and administered preloads of 20 mL · kg−1 HES 130/0.4 and 5% HA, respectively, prior to dura opening. Primary outcomes were perioperative thromboelastography findings, and hemodynamic and hematological parameters. Blood transfusion, perioperative fluid balance, intracranial pressure, mortality, intensive care unit stay, and hospital stay were also assessed. Results TEG parameters did not differ after preloading compared to baseline values in either group, except for a decrease in maximum amplitude immediately after infusion (HES group, 57.6 ± 6.0 mm vs. 50.9 ± 9.2 mm; HA group, 60.1 ± 7.9 mm vs. 56.6 ± 7.1 mm; p < 0.01), which was restored to preoperative levels 1 h after fluid infusion. Total perioperative fluid balance, blood loss or transfusion, intracranial pressure, and hematological and hemodynamic variables were similar between both groups (p > 0.05). Mortality, length of hospital stay, and clinical complications were similar between both groups. Conclusion These findings suggest that HES and HA might have no significant differences regarding coagulation as assessed by TEG during pediatric intracranial tumor surgery with 20 ml/kg volume pre-loading, which can maintain stable hemodynamics and may represent a new avenue for volume therapy during brain tumor resection in pediatrics. Trial registration ChiCTR-IPR- 16009333 , retrospectively registered October 8, 2016 |
| first_indexed | 2024-04-12T22:02:14Z |
| format | Article |
| id | doaj.art-dcd940045f6a410b864ffec06fcc184d |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-04-12T22:02:14Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-dcd940045f6a410b864ffec06fcc184d2022-12-22T03:15:04ZengBMCBMC Anesthesiology1471-22532017-04-011711710.1186/s12871-017-0353-zEffects of colloid pre-loading on thromboelastography during elective intracranial tumor surgery in pediatric patients: hydroxyethyl starch 130/0.4 versus 5% human albuminYuanzhi Peng0Jianer Du1Xuan Zhao2Xueyin Shi3Yingwei Wang4Department of Anesthesiology, Xinhua Hospital Affiliated to Shanghai Jiao TongDepartment of Anesthesiology, Xinhua Hospital Affiliated to Shanghai Jiao TongDepartment of Anesthesiology, Xinhua Hospital Affiliated to Shanghai Jiao TongDepartment of Anesthesiology, Xinhua Hospital Affiliated to Shanghai Jiao TongDepartment of Anesthesiology, Huashan Hospital, FuDan UniversityAbstract Background Volume replacement therapy with colloid is still worth studying in major pediatric surgery with potential risk of bleeding. This study assessed the effects of 6% hydroxyethyl starch (HES) 130/0.4 and 5% Human Albumin (HA) on coagulation tested by thromboelastography (TEG) during elective intracranial tumor surgery in pediatric patients. Methods In this randomized controlled trial, 60 patients undergoing intracranial tumor resection under general anesthesia were assigned to HES and HA groups (n = 30), and administered preloads of 20 mL · kg−1 HES 130/0.4 and 5% HA, respectively, prior to dura opening. Primary outcomes were perioperative thromboelastography findings, and hemodynamic and hematological parameters. Blood transfusion, perioperative fluid balance, intracranial pressure, mortality, intensive care unit stay, and hospital stay were also assessed. Results TEG parameters did not differ after preloading compared to baseline values in either group, except for a decrease in maximum amplitude immediately after infusion (HES group, 57.6 ± 6.0 mm vs. 50.9 ± 9.2 mm; HA group, 60.1 ± 7.9 mm vs. 56.6 ± 7.1 mm; p < 0.01), which was restored to preoperative levels 1 h after fluid infusion. Total perioperative fluid balance, blood loss or transfusion, intracranial pressure, and hematological and hemodynamic variables were similar between both groups (p > 0.05). Mortality, length of hospital stay, and clinical complications were similar between both groups. Conclusion These findings suggest that HES and HA might have no significant differences regarding coagulation as assessed by TEG during pediatric intracranial tumor surgery with 20 ml/kg volume pre-loading, which can maintain stable hemodynamics and may represent a new avenue for volume therapy during brain tumor resection in pediatrics. Trial registration ChiCTR-IPR- 16009333 , retrospectively registered October 8, 2016http://link.springer.com/article/10.1186/s12871-017-0353-zHydroxyethyl starch 130/0.4ThromboelastographyPediatricIntracranial tumor surgery |
| spellingShingle | Yuanzhi Peng Jianer Du Xuan Zhao Xueyin Shi Yingwei Wang Effects of colloid pre-loading on thromboelastography during elective intracranial tumor surgery in pediatric patients: hydroxyethyl starch 130/0.4 versus 5% human albumin BMC Anesthesiology Hydroxyethyl starch 130/0.4 Thromboelastography Pediatric Intracranial tumor surgery |
| title | Effects of colloid pre-loading on thromboelastography during elective intracranial tumor surgery in pediatric patients: hydroxyethyl starch 130/0.4 versus 5% human albumin |
| title_full | Effects of colloid pre-loading on thromboelastography during elective intracranial tumor surgery in pediatric patients: hydroxyethyl starch 130/0.4 versus 5% human albumin |
| title_fullStr | Effects of colloid pre-loading on thromboelastography during elective intracranial tumor surgery in pediatric patients: hydroxyethyl starch 130/0.4 versus 5% human albumin |
| title_full_unstemmed | Effects of colloid pre-loading on thromboelastography during elective intracranial tumor surgery in pediatric patients: hydroxyethyl starch 130/0.4 versus 5% human albumin |
| title_short | Effects of colloid pre-loading on thromboelastography during elective intracranial tumor surgery in pediatric patients: hydroxyethyl starch 130/0.4 versus 5% human albumin |
| title_sort | effects of colloid pre loading on thromboelastography during elective intracranial tumor surgery in pediatric patients hydroxyethyl starch 130 0 4 versus 5 human albumin |
| topic | Hydroxyethyl starch 130/0.4 Thromboelastography Pediatric Intracranial tumor surgery |
| url | http://link.springer.com/article/10.1186/s12871-017-0353-z |
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