Treatment for acute promyelocytic leukemia during pregnancy
AIM: To study the experience in managing patients with acute promyelocytic leukemia (APL) diagnosed in different periods of pregnancy/MATERIAL AND METHODS: Nine women with APL were treated in 1998-2013. When APL was diagnosed in the first trimester of pregnancy, the latter was terminated (n=1); when...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2013-10-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31345 |
| _version_ | 1818326592810647552 |
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| author | V V Troitskaia E N Parovichnikova A N Sokolov A V Kokhno S A Makhinia G M Galstian T S Konstantinova L A Mazurok I G Goriachok A V Korobkin M A Liubchenko O A Latyshkevich A V Zvereva M A Kurtser V G Savchenko |
| author_facet | V V Troitskaia E N Parovichnikova A N Sokolov A V Kokhno S A Makhinia G M Galstian T S Konstantinova L A Mazurok I G Goriachok A V Korobkin M A Liubchenko O A Latyshkevich A V Zvereva M A Kurtser V G Savchenko |
| author_sort | V V Troitskaia |
| collection | DOAJ |
| description | AIM: To study the experience in managing patients with acute promyelocytic leukemia (APL) diagnosed in different periods of pregnancy/MATERIAL AND METHODS: Nine women with APL were treated in 1998-2013. When APL was diagnosed in the first trimester of pregnancy, the latter was terminated (n=1); when its diagnosis was made in the second trimester, chemotherapy (CT) followed by delivery (D) was performed (n=3); when it was done in the third trimester, D followed by CT was done in relation to gestational age (n=2) or these were performed at a later gestational age (n=1). APL was treated in 5 and 1 patients according to the AIDA protocol and the 7+3 plus ATRA one, respectively/RESULTS: All the patients with APL achieved remission after the first cycle of induction CT; 5 of the 6 patients did at the moment of delivery; one patient underwent emergency delivery during cytopenia after the cycle. The gestational age at delivery after CT was 34 (34-40) weeks. Spontaneous term labor occurred in 2 patients at an obstetric hospital. Cesarean section was made in 4 of the 6 patients. All babies were born alive, healthy, and without developmental abnormalities. Their age at the time of analyzing the results was 2.5 months to 15 years. Four of the 9 patients are presently alive. Late recurrences occurred in 3 (33%) patients. The median overall survival is 26 (0.25-128) months; the median relapse-free survival is 17.5 (0-127) months/CONCLUSION: APL treatment in pregnant women, which is aimed at saving two lives, is effective and reasonable. |
| first_indexed | 2024-12-13T12:02:50Z |
| format | Article |
| id | doaj.art-dcd9bd17df2e45c083463c1a4c005330 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T12:02:50Z |
| publishDate | 2013-10-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-dcd9bd17df2e45c083463c1a4c0053302022-12-21T23:47:03Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422013-10-018510566328361Treatment for acute promyelocytic leukemia during pregnancyV V TroitskaiaE N ParovichnikovaA N SokolovA V KokhnoS A MakhiniaG M GalstianT S KonstantinovaL A MazurokI G GoriachokA V KorobkinM A LiubchenkoO A LatyshkevichA V ZverevaM A KurtserV G SavchenkoAIM: To study the experience in managing patients with acute promyelocytic leukemia (APL) diagnosed in different periods of pregnancy/MATERIAL AND METHODS: Nine women with APL were treated in 1998-2013. When APL was diagnosed in the first trimester of pregnancy, the latter was terminated (n=1); when its diagnosis was made in the second trimester, chemotherapy (CT) followed by delivery (D) was performed (n=3); when it was done in the third trimester, D followed by CT was done in relation to gestational age (n=2) or these were performed at a later gestational age (n=1). APL was treated in 5 and 1 patients according to the AIDA protocol and the 7+3 plus ATRA one, respectively/RESULTS: All the patients with APL achieved remission after the first cycle of induction CT; 5 of the 6 patients did at the moment of delivery; one patient underwent emergency delivery during cytopenia after the cycle. The gestational age at delivery after CT was 34 (34-40) weeks. Spontaneous term labor occurred in 2 patients at an obstetric hospital. Cesarean section was made in 4 of the 6 patients. All babies were born alive, healthy, and without developmental abnormalities. Their age at the time of analyzing the results was 2.5 months to 15 years. Four of the 9 patients are presently alive. Late recurrences occurred in 3 (33%) patients. The median overall survival is 26 (0.25-128) months; the median relapse-free survival is 17.5 (0-127) months/CONCLUSION: APL treatment in pregnant women, which is aimed at saving two lives, is effective and reasonable.https://ter-arkhiv.ru/0040-3660/article/view/31345acute promyelocytic leukemiapregnancychemotherapyall-trans retinoic acid (atra)atra |
| spellingShingle | V V Troitskaia E N Parovichnikova A N Sokolov A V Kokhno S A Makhinia G M Galstian T S Konstantinova L A Mazurok I G Goriachok A V Korobkin M A Liubchenko O A Latyshkevich A V Zvereva M A Kurtser V G Savchenko Treatment for acute promyelocytic leukemia during pregnancy Терапевтический архив acute promyelocytic leukemia pregnancy chemotherapy all-trans retinoic acid (atra) atra |
| title | Treatment for acute promyelocytic leukemia during pregnancy |
| title_full | Treatment for acute promyelocytic leukemia during pregnancy |
| title_fullStr | Treatment for acute promyelocytic leukemia during pregnancy |
| title_full_unstemmed | Treatment for acute promyelocytic leukemia during pregnancy |
| title_short | Treatment for acute promyelocytic leukemia during pregnancy |
| title_sort | treatment for acute promyelocytic leukemia during pregnancy |
| topic | acute promyelocytic leukemia pregnancy chemotherapy all-trans retinoic acid (atra) atra |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31345 |
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