Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage
Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and pathological conditions. Such modifications depend on...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/5/749 |
| _version_ | 1797534900141686784 |
|---|---|
| author | Mabel Buelna-Chontal Wylly R. García-Niño Alejandro Silva-Palacios Cristina Enríquez-Cortina Cecilia Zazueta |
| author_facet | Mabel Buelna-Chontal Wylly R. García-Niño Alejandro Silva-Palacios Cristina Enríquez-Cortina Cecilia Zazueta |
| author_sort | Mabel Buelna-Chontal |
| collection | DOAJ |
| description | Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and pathological conditions. Such modifications depend on the generation of redox components, such as reactive oxygen species and nitric oxide. Therefore, as the oxidative or nitrosative milieu prevailing in the reperfused heart is determinant for protective signaling, in this review we defined the impact of redox-based post-translational modifications resulting from either oxidative/nitrosative signaling or oxidative/nitrosative stress that occurs during reperfusion damage. The role that cardioprotective conditioning strategies have had to establish that such changes occur at different subcellular levels, particularly in mitochondria, is also presented. Another section is devoted to the possible mechanism of signal delivering of modified proteins. Finally, we discuss the possible efficacy of redox-based therapeutic strategies against reperfusion damage. |
| first_indexed | 2024-03-10T11:37:01Z |
| format | Article |
| id | doaj.art-dcdc720a462741dfba6f138d069026dd |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T11:37:01Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-dcdc720a462741dfba6f138d069026dd2023-11-21T18:49:02ZengMDPI AGAntioxidants2076-39212021-05-0110574910.3390/antiox10050749Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion DamageMabel Buelna-Chontal0Wylly R. García-Niño1Alejandro Silva-Palacios2Cristina Enríquez-Cortina3Cecilia Zazueta4Department of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, MexicoDepartment of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, MexicoDepartment of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, MexicoDepartment of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, MexicoDepartment of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, MexicoPost-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and pathological conditions. Such modifications depend on the generation of redox components, such as reactive oxygen species and nitric oxide. Therefore, as the oxidative or nitrosative milieu prevailing in the reperfused heart is determinant for protective signaling, in this review we defined the impact of redox-based post-translational modifications resulting from either oxidative/nitrosative signaling or oxidative/nitrosative stress that occurs during reperfusion damage. The role that cardioprotective conditioning strategies have had to establish that such changes occur at different subcellular levels, particularly in mitochondria, is also presented. Another section is devoted to the possible mechanism of signal delivering of modified proteins. Finally, we discuss the possible efficacy of redox-based therapeutic strategies against reperfusion damage.https://www.mdpi.com/2076-3921/10/5/749oxidative post-translational modificationnitrosative post-translational modificationreperfusion damagemitochondria |
| spellingShingle | Mabel Buelna-Chontal Wylly R. García-Niño Alejandro Silva-Palacios Cristina Enríquez-Cortina Cecilia Zazueta Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage Antioxidants oxidative post-translational modification nitrosative post-translational modification reperfusion damage mitochondria |
| title | Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
| title_full | Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
| title_fullStr | Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
| title_full_unstemmed | Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
| title_short | Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage |
| title_sort | implications of oxidative and nitrosative post translational modifications in therapeutic strategies against reperfusion damage |
| topic | oxidative post-translational modification nitrosative post-translational modification reperfusion damage mitochondria |
| url | https://www.mdpi.com/2076-3921/10/5/749 |
| work_keys_str_mv | AT mabelbuelnachontal implicationsofoxidativeandnitrosativeposttranslationalmodificationsintherapeuticstrategiesagainstreperfusiondamage AT wyllyrgarcianino implicationsofoxidativeandnitrosativeposttranslationalmodificationsintherapeuticstrategiesagainstreperfusiondamage AT alejandrosilvapalacios implicationsofoxidativeandnitrosativeposttranslationalmodificationsintherapeuticstrategiesagainstreperfusiondamage AT cristinaenriquezcortina implicationsofoxidativeandnitrosativeposttranslationalmodificationsintherapeuticstrategiesagainstreperfusiondamage AT ceciliazazueta implicationsofoxidativeandnitrosativeposttranslationalmodificationsintherapeuticstrategiesagainstreperfusiondamage |