Immunogenic cell death-inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapy
Chemotherapeutic nanoformulations, which can induce the immunogenic death of tumor cells, have attracted increasing attention for their abilities to enable and potentiate combination chemoimmunotherapy. Immunogenic cell death (ICD) causes the release of tumor-associated antigens, tumor-specific anti...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127521000186 |
| _version_ | 1818440467474284544 |
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| author | Jianhua Liu Zhongmin Li Duoyi Zhao Xiangru Feng Chunxi Wang Di Li Jianxun Ding |
| author_facet | Jianhua Liu Zhongmin Li Duoyi Zhao Xiangru Feng Chunxi Wang Di Li Jianxun Ding |
| author_sort | Jianhua Liu |
| collection | DOAJ |
| description | Chemotherapeutic nanoformulations, which can induce the immunogenic death of tumor cells, have attracted increasing attention for their abilities to enable and potentiate combination chemoimmunotherapy. Immunogenic cell death (ICD) causes the release of tumor-associated antigens, tumor-specific antigens, danger-associated molecular patterns, and pro-inflammatory cytokines, which trigger adaptive immune cells to elicit an antitumor immune response. The combination of ICD-inducing nanomedicines and immunoactivators represents a promising strategy for enhancing chemoimmunotherapy in clinical applications. In this review, we provide an overview of the latest advances in chemotherapeutic nanoformulation-mediated immune activation and the combination strategies with various immunoactivating agents, such as immune checkpoint inhibitors, indoleamine 2,3-dioxygenase inhibitors, cytokines, and Toll-like receptor agonists, and predict their potential to contribute significantly to clinical cancer chemoimmunotherapy. |
| first_indexed | 2024-12-14T18:12:49Z |
| format | Article |
| id | doaj.art-dcdcd8fe6beb47e7ba6eca5e4ae15485 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-14T18:12:49Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-dcdcd8fe6beb47e7ba6eca5e4ae154852022-12-21T22:52:15ZengElsevierMaterials & Design0264-12752021-04-01202109465Immunogenic cell death-inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapyJianhua Liu0Zhongmin Li1Duoyi Zhao2Xiangru Feng3Chunxi Wang4Di Li5Jianxun Ding6Department of Urology, The First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, PR ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR China; Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, PR ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR ChinaDepartment of Urology, The First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, PR China; Corresponding authors.Department of Hepatobiliary and Pancreatic Surgery, the First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, PR China; Corresponding authors.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR ChinaChemotherapeutic nanoformulations, which can induce the immunogenic death of tumor cells, have attracted increasing attention for their abilities to enable and potentiate combination chemoimmunotherapy. Immunogenic cell death (ICD) causes the release of tumor-associated antigens, tumor-specific antigens, danger-associated molecular patterns, and pro-inflammatory cytokines, which trigger adaptive immune cells to elicit an antitumor immune response. The combination of ICD-inducing nanomedicines and immunoactivators represents a promising strategy for enhancing chemoimmunotherapy in clinical applications. In this review, we provide an overview of the latest advances in chemotherapeutic nanoformulation-mediated immune activation and the combination strategies with various immunoactivating agents, such as immune checkpoint inhibitors, indoleamine 2,3-dioxygenase inhibitors, cytokines, and Toll-like receptor agonists, and predict their potential to contribute significantly to clinical cancer chemoimmunotherapy.http://www.sciencedirect.com/science/article/pii/S0264127521000186NanomaterialChemotherapeutic agentImmunogenic cell deathImmunomodulatory factorChemoimmunotherapy |
| spellingShingle | Jianhua Liu Zhongmin Li Duoyi Zhao Xiangru Feng Chunxi Wang Di Li Jianxun Ding Immunogenic cell death-inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapy Materials & Design Nanomaterial Chemotherapeutic agent Immunogenic cell death Immunomodulatory factor Chemoimmunotherapy |
| title | Immunogenic cell death-inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapy |
| title_full | Immunogenic cell death-inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapy |
| title_fullStr | Immunogenic cell death-inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapy |
| title_full_unstemmed | Immunogenic cell death-inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapy |
| title_short | Immunogenic cell death-inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapy |
| title_sort | immunogenic cell death inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapy |
| topic | Nanomaterial Chemotherapeutic agent Immunogenic cell death Immunomodulatory factor Chemoimmunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S0264127521000186 |
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