Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions
This review aims to provide a comprehensive understanding of the molecular mechanisms underlying autophagy and mitophagy in hepatocellular carcinoma (HCC). Autophagy is an essential cellular process in maintaining cell homeostasis. Still, its dysregulation is associated with the development of liver...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/22/16255 |
| _version_ | 1797459012454711296 |
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| author | Thi Ha Nguyen Tuan Minh Nguyen Dinh Thi Minh Ngoc Taesik You Mi Kyung Park Chang Hoon Lee |
| author_facet | Thi Ha Nguyen Tuan Minh Nguyen Dinh Thi Minh Ngoc Taesik You Mi Kyung Park Chang Hoon Lee |
| author_sort | Thi Ha Nguyen |
| collection | DOAJ |
| description | This review aims to provide a comprehensive understanding of the molecular mechanisms underlying autophagy and mitophagy in hepatocellular carcinoma (HCC). Autophagy is an essential cellular process in maintaining cell homeostasis. Still, its dysregulation is associated with the development of liver diseases, including HCC, which is one of leading causes of cancer-related death worldwide. We focus on elucidating the dual role of autophagy in HCC, both in tumor initiation and progression, and highlighting the complex nature involved in the disease. In addition, we present a detailed analysis of a small subset of autophagy- and mitophagy-related molecules, revealing their specific functions during tumorigenesis and the progression of HCC cells. By understanding these mechanisms, we aim to provide valuable insights into potential therapeutic strategies to manipulate autophagy effectively. The goal is to improve the therapeutic response of liver cancer cells and overcome drug resistance, providing new avenues for improved treatment options for HCC patients. Overall, this review serves as a valuable resource for researchers and clinicians interested in the complex role of autophagy in HCC and its potential as a target for innovative therapies aimed to combat this devastating disease. |
| first_indexed | 2024-03-09T16:46:22Z |
| format | Article |
| id | doaj.art-dcde081c45804fbb8928a11f415a0e93 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:46:22Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dcde081c45804fbb8928a11f415a0e932023-11-24T14:46:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124221625510.3390/ijms242216255Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic InterventionsThi Ha Nguyen0Tuan Minh Nguyen1Dinh Thi Minh Ngoc2Taesik You3Mi Kyung Park4Chang Hoon Lee5College of Pharmacy, Dongguk University, Seoul 04620, Republic of KoreaCollege of Pharmacy, Dongguk University, Seoul 04620, Republic of KoreaCollege of Pharmacy, Dongguk University, Seoul 04620, Republic of KoreaCollege of Pharmacy, Dongguk University, Seoul 04620, Republic of KoreaDepartment of Cancer Biomedical Science, Graduate School of Cancer Science and Policy National Cance Center, Goyang 10408, Republic of KoreaCollege of Pharmacy, Dongguk University, Seoul 04620, Republic of KoreaThis review aims to provide a comprehensive understanding of the molecular mechanisms underlying autophagy and mitophagy in hepatocellular carcinoma (HCC). Autophagy is an essential cellular process in maintaining cell homeostasis. Still, its dysregulation is associated with the development of liver diseases, including HCC, which is one of leading causes of cancer-related death worldwide. We focus on elucidating the dual role of autophagy in HCC, both in tumor initiation and progression, and highlighting the complex nature involved in the disease. In addition, we present a detailed analysis of a small subset of autophagy- and mitophagy-related molecules, revealing their specific functions during tumorigenesis and the progression of HCC cells. By understanding these mechanisms, we aim to provide valuable insights into potential therapeutic strategies to manipulate autophagy effectively. The goal is to improve the therapeutic response of liver cancer cells and overcome drug resistance, providing new avenues for improved treatment options for HCC patients. Overall, this review serves as a valuable resource for researchers and clinicians interested in the complex role of autophagy in HCC and its potential as a target for innovative therapies aimed to combat this devastating disease.https://www.mdpi.com/1422-0067/24/22/16255hepatocellular carcinomaautophagymitophagyautophagy inhibitorsautophagy inducer |
| spellingShingle | Thi Ha Nguyen Tuan Minh Nguyen Dinh Thi Minh Ngoc Taesik You Mi Kyung Park Chang Hoon Lee Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions International Journal of Molecular Sciences hepatocellular carcinoma autophagy mitophagy autophagy inhibitors autophagy inducer |
| title | Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions |
| title_full | Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions |
| title_fullStr | Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions |
| title_full_unstemmed | Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions |
| title_short | Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions |
| title_sort | unraveling the janus faced role of autophagy in hepatocellular carcinoma implications for therapeutic interventions |
| topic | hepatocellular carcinoma autophagy mitophagy autophagy inhibitors autophagy inducer |
| url | https://www.mdpi.com/1422-0067/24/22/16255 |
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