The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters
One of the most important functions of skin is to act as a protective barrier. To fulfill this role, the structural integrity of the skin depends on the dermal-epidermal junction—a complex network of extracellular matrix macromolecules that connect the outer epidermal layer to the underlying dermis....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/12/1607 |
| _version_ | 1797546555440365568 |
|---|---|
| author | Eva Roig-Rosello Patricia Rousselle |
| author_facet | Eva Roig-Rosello Patricia Rousselle |
| author_sort | Eva Roig-Rosello |
| collection | DOAJ |
| description | One of the most important functions of skin is to act as a protective barrier. To fulfill this role, the structural integrity of the skin depends on the dermal-epidermal junction—a complex network of extracellular matrix macromolecules that connect the outer epidermal layer to the underlying dermis. This junction provides both a structural support to keratinocytes and a specific niche that mediates signals influencing their behavior. It displays a distinctive microarchitecture characterized by an undulating pattern, strengthening dermal-epidermal connectivity and crosstalk. The optimal stiffness arising from the overall molecular organization, together with characteristic anchoring complexes, keeps the dermis and epidermis layers extremely well connected and capable of proper epidermal renewal and regeneration. Due to intrinsic and extrinsic factors, a large number of structural and biological changes accompany skin aging. These changes progressively weaken the dermal–epidermal junction substructure and affect its functions, contributing to the gradual decline in overall skin physiology. Most changes involve reduced turnover or altered enzymatic or non-enzymatic post-translational modifications, compromising the mechanical properties of matrix components and cells. This review combines recent and older data on organization of the dermal-epidermal junction, its mechanical properties and role in mechanotransduction, its involvement in regeneration, and its fate during the aging process. |
| first_indexed | 2024-03-10T14:31:28Z |
| format | Article |
| id | doaj.art-dcde4e9914044249beb569d54ad2f219 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T14:31:28Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-dcde4e9914044249beb569d54ad2f2192023-11-20T22:35:04ZengMDPI AGBiomolecules2218-273X2020-11-011012160710.3390/biom10121607The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly AltersEva Roig-Rosello0Patricia Rousselle1Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, UMR 5305, CNRS-Université Lyon 1, SFR BioSciences Gerland-Lyon Sud, 7 Passage du Vercors, 69367 Lyon, FranceLaboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, UMR 5305, CNRS-Université Lyon 1, SFR BioSciences Gerland-Lyon Sud, 7 Passage du Vercors, 69367 Lyon, FranceOne of the most important functions of skin is to act as a protective barrier. To fulfill this role, the structural integrity of the skin depends on the dermal-epidermal junction—a complex network of extracellular matrix macromolecules that connect the outer epidermal layer to the underlying dermis. This junction provides both a structural support to keratinocytes and a specific niche that mediates signals influencing their behavior. It displays a distinctive microarchitecture characterized by an undulating pattern, strengthening dermal-epidermal connectivity and crosstalk. The optimal stiffness arising from the overall molecular organization, together with characteristic anchoring complexes, keeps the dermis and epidermis layers extremely well connected and capable of proper epidermal renewal and regeneration. Due to intrinsic and extrinsic factors, a large number of structural and biological changes accompany skin aging. These changes progressively weaken the dermal–epidermal junction substructure and affect its functions, contributing to the gradual decline in overall skin physiology. Most changes involve reduced turnover or altered enzymatic or non-enzymatic post-translational modifications, compromising the mechanical properties of matrix components and cells. This review combines recent and older data on organization of the dermal-epidermal junction, its mechanical properties and role in mechanotransduction, its involvement in regeneration, and its fate during the aging process.https://www.mdpi.com/2218-273X/10/12/1607extracellular matrixbasement membranedermal-epidermal junctionskinepidermal rete-ridgedermal papilla |
| spellingShingle | Eva Roig-Rosello Patricia Rousselle The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters Biomolecules extracellular matrix basement membrane dermal-epidermal junction skin epidermal rete-ridge dermal papilla |
| title | The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters |
| title_full | The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters |
| title_fullStr | The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters |
| title_full_unstemmed | The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters |
| title_short | The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters |
| title_sort | human epidermal basement membrane a shaped and cell instructive platform that aging slowly alters |
| topic | extracellular matrix basement membrane dermal-epidermal junction skin epidermal rete-ridge dermal papilla |
| url | https://www.mdpi.com/2218-273X/10/12/1607 |
| work_keys_str_mv | AT evaroigrosello thehumanepidermalbasementmembraneashapedandcellinstructiveplatformthatagingslowlyalters AT patriciarousselle thehumanepidermalbasementmembraneashapedandcellinstructiveplatformthatagingslowlyalters AT evaroigrosello humanepidermalbasementmembraneashapedandcellinstructiveplatformthatagingslowlyalters AT patriciarousselle humanepidermalbasementmembraneashapedandcellinstructiveplatformthatagingslowlyalters |