Cell proliferation and neurogenesis in adult mouse brain.
Neurogenesis, the formation of new neurons, can be observed in the adult brain of many mammalian species, including humans. Despite significant progress in our understanding of adult neurogenesis, we are still missing data about the extent and location of production of neural precursors in the adult...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4222938?pdf=render |
| _version_ | 1818013723075280896 |
|---|---|
| author | Olivia L Bordiuk Karen Smith Peter J Morin Mikhail V Semënov |
| author_facet | Olivia L Bordiuk Karen Smith Peter J Morin Mikhail V Semënov |
| author_sort | Olivia L Bordiuk |
| collection | DOAJ |
| description | Neurogenesis, the formation of new neurons, can be observed in the adult brain of many mammalian species, including humans. Despite significant progress in our understanding of adult neurogenesis, we are still missing data about the extent and location of production of neural precursors in the adult mammalian brain. We used 5-ethynyl-2'-deoxyuridine (EdU) to map the location of proliferating cells throughout the entire adult mouse brain and found that neurogenesis occurs at two locations in the mouse brain. The larger one we define as the main proliferative zone (MPZ), and the smaller one corresponds to the subgranular zone of the hippocampus. The MPZ can be divided into three parts. The caudate migratory stream (CMS) occupies the middle part of the MPZ. The cable of proliferating cells emanating from the most anterior part of the CMS toward the olfactory bulbs forms the rostral migratory stream. The thin layer of proliferating cells extending posteriorly from the CMS forms the midlayer. We have not found any additional aggregations of proliferating cells in the adult mouse brain that could suggest the existence of other major neurogenic zones in the adult mouse brain. |
| first_indexed | 2024-04-14T06:37:53Z |
| format | Article |
| id | doaj.art-dcdea65ad9614366a0eaaba6314c71f5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T06:37:53Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dcdea65ad9614366a0eaaba6314c71f52022-12-22T02:07:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11145310.1371/journal.pone.0111453Cell proliferation and neurogenesis in adult mouse brain.Olivia L BordiukKaren SmithPeter J MorinMikhail V SemënovNeurogenesis, the formation of new neurons, can be observed in the adult brain of many mammalian species, including humans. Despite significant progress in our understanding of adult neurogenesis, we are still missing data about the extent and location of production of neural precursors in the adult mammalian brain. We used 5-ethynyl-2'-deoxyuridine (EdU) to map the location of proliferating cells throughout the entire adult mouse brain and found that neurogenesis occurs at two locations in the mouse brain. The larger one we define as the main proliferative zone (MPZ), and the smaller one corresponds to the subgranular zone of the hippocampus. The MPZ can be divided into three parts. The caudate migratory stream (CMS) occupies the middle part of the MPZ. The cable of proliferating cells emanating from the most anterior part of the CMS toward the olfactory bulbs forms the rostral migratory stream. The thin layer of proliferating cells extending posteriorly from the CMS forms the midlayer. We have not found any additional aggregations of proliferating cells in the adult mouse brain that could suggest the existence of other major neurogenic zones in the adult mouse brain.http://europepmc.org/articles/PMC4222938?pdf=render |
| spellingShingle | Olivia L Bordiuk Karen Smith Peter J Morin Mikhail V Semënov Cell proliferation and neurogenesis in adult mouse brain. PLoS ONE |
| title | Cell proliferation and neurogenesis in adult mouse brain. |
| title_full | Cell proliferation and neurogenesis in adult mouse brain. |
| title_fullStr | Cell proliferation and neurogenesis in adult mouse brain. |
| title_full_unstemmed | Cell proliferation and neurogenesis in adult mouse brain. |
| title_short | Cell proliferation and neurogenesis in adult mouse brain. |
| title_sort | cell proliferation and neurogenesis in adult mouse brain |
| url | http://europepmc.org/articles/PMC4222938?pdf=render |
| work_keys_str_mv | AT olivialbordiuk cellproliferationandneurogenesisinadultmousebrain AT karensmith cellproliferationandneurogenesisinadultmousebrain AT peterjmorin cellproliferationandneurogenesisinadultmousebrain AT mikhailvsemenov cellproliferationandneurogenesisinadultmousebrain |