Molecular Mechanisms of Cardiac Amyloidosis
Cardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, and the prognosis has been improved....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/1/25 |
| _version_ | 1797498975733940224 |
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| author | Yukihiro Saito Kazufumi Nakamura Hiroshi Ito |
| author_facet | Yukihiro Saito Kazufumi Nakamura Hiroshi Ito |
| author_sort | Yukihiro Saito |
| collection | DOAJ |
| description | Cardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, and the prognosis has been improved. However, a method for removing deposited amyloid has not been established. Methods for reducing cytotoxicity caused by amyloid deposition and amyloid precursor protein to protect cardiovascular cells are also needed. In this review, we outline the molecular mechanisms and treatments of cardiac amyloidosis. |
| first_indexed | 2024-03-10T03:40:58Z |
| format | Article |
| id | doaj.art-dce00a603ca54c55af808b88fb7fac68 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:40:58Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dce00a603ca54c55af808b88fb7fac682023-11-23T11:33:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-012312510.3390/ijms23010025Molecular Mechanisms of Cardiac AmyloidosisYukihiro Saito0Kazufumi Nakamura1Hiroshi Ito2Department of Cardiovascular Medicine, Okayama University Hospital, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanCardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, and the prognosis has been improved. However, a method for removing deposited amyloid has not been established. Methods for reducing cytotoxicity caused by amyloid deposition and amyloid precursor protein to protect cardiovascular cells are also needed. In this review, we outline the molecular mechanisms and treatments of cardiac amyloidosis.https://www.mdpi.com/1422-0067/23/1/25amyloidcytotoxicitytransthyretinimmunoglobulin light chain |
| spellingShingle | Yukihiro Saito Kazufumi Nakamura Hiroshi Ito Molecular Mechanisms of Cardiac Amyloidosis International Journal of Molecular Sciences amyloid cytotoxicity transthyretin immunoglobulin light chain |
| title | Molecular Mechanisms of Cardiac Amyloidosis |
| title_full | Molecular Mechanisms of Cardiac Amyloidosis |
| title_fullStr | Molecular Mechanisms of Cardiac Amyloidosis |
| title_full_unstemmed | Molecular Mechanisms of Cardiac Amyloidosis |
| title_short | Molecular Mechanisms of Cardiac Amyloidosis |
| title_sort | molecular mechanisms of cardiac amyloidosis |
| topic | amyloid cytotoxicity transthyretin immunoglobulin light chain |
| url | https://www.mdpi.com/1422-0067/23/1/25 |
| work_keys_str_mv | AT yukihirosaito molecularmechanismsofcardiacamyloidosis AT kazufuminakamura molecularmechanismsofcardiacamyloidosis AT hiroshiito molecularmechanismsofcardiacamyloidosis |