Immune Memory After Respiratory Infection With Streptococcus pneumoniae Is Revealed by in vitro Stimulation of Murine Splenocytes With Inactivated Pneumococcal Whole Cells: Evidence of Early Recall Responses by Transcriptomic Analysis

Immune Memory After Respiratory Infection With Streptococcus pneumoniae Is Revealed by in vitro Stimulation of Murine Splenocytes With Inactivated Pneumococcal Whole Cells: Evidence of Early Recall Responses by Transcriptomic Analysis

The in vitro stimulation of immune system cells with live or killed bacteria is essential for understanding the host response to pathogens. In the present study, we propose a model combining transcriptomic and cytokine assays on murine splenocytes to describe the immune recall in the days following...

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Bibliographic Details
Main Authors: Isabelle Franco Moscardini, Francesco Santoro, Monica Carraro, Alice Gerlini, Fabio Fiorino, Chiara Germoni, Samaneh Gholami, Elena Pettini, Donata Medaglini, Francesco Iannelli, Gianni Pozzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Streptococcus pneumoniae
in vitro stimulation
Transcriptomic Analysis
Recall immune responses
lung infection
cytokines/chemokines
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.869763/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.869763/full

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